Enhancing in vitro biocompatibility and corrosion protection of organic-inorganic hybrid sol-gel films with nanocrystalline hydroxyapatite

Application of novel organic-inorganic hybrid sol-gel coatings containing dispersed hydroxyapatite (HAp) particles improves the biocompatibility, normal human osteoblast (NHOst) response in terms of osteoblast viability and adhesion of a Ti6Al4V alloy routinely used in medical implants. The incorpor...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2014-06, Vol.2 (24), p.3886-3896
Main Authors: El Hadad, A A, Barranco, V, Jiménez-Morales, A, Peón, E, Hickman, G J, Perry, C C, Galván, J C
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Corrosion prevention
Crosslinking
Hydroxyapatite
Protective coatings
Sol gel process
Titanium base alloys
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Summary:Application of novel organic-inorganic hybrid sol-gel coatings containing dispersed hydroxyapatite (HAp) particles improves the biocompatibility, normal human osteoblast (NHOst) response in terms of osteoblast viability and adhesion of a Ti6Al4V alloy routinely used in medical implants. The incorporation of HAp particles additionally results in more effective barrier proprieties and improved corrosion protection of the Ti6Al4V alloy through higher degree of cross-linking in the organopolysiloxane matrix and enhanced film thickness.
ISSN:2050-750X
2050-7518
DOI:10.1039/c4tb00173g