Assembly and antifungal effect of a new fluconazole-carrier nanosystem

To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration d...

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Bibliographic Details
Published in:Future microbiology 2020-03, Vol.15 (4), p.273-285
Main Authors: de Lima, Taynara Mt, Arias, Laís S, Afanaci, Letícia F, Ferraresse, Raphael Fb, de S Neto, Francisco N, de Lima, Bruno Hr, Straioto, Fabiana G, de Camargo, Emerson R, Pessan, Juliano P, Monteiro, Douglas R
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal agents
Biofilms
Carbohydrates
Chitosan
Drugs
Extracellular matrix
Fluconazole
Infections
iron oxide nanoparticles
Iron oxides
Metabolism
Microscopy
Minimum inhibitory concentration
Nanoparticles
Planktonic cells
Software
Statistical analysis
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Summary:To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of and . Characterization results ratified the formation of a nanosystem (
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2019-0182