Anti‐MDA5‐associated dermatomyositis

Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly p...

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Bibliographic Details
Published in:Internal medicine journal 2020-04, Vol.50 (4), p.484-487
Main Authors: Gupta, Rajiv, Kumar, Sunil, Gow, Peter, (Hsien‐Cheng) Chang, Leon, Yen, Linda
Format: Article
Language:English
Subjects:
anti‐MDA5‐associated dermatomyositis
Autoantibodies
cyclosporine
Dermatomyositis
Dermatomyositis - complications
Dermatomyositis - diagnosis
Dermatomyositis - drug therapy
Humans
Inflammation
inflammatory myopathy
intravenous immunoglobulins
Lung diseases
Lung Diseases, Interstitial - diagnostic imaging
Lung Diseases, Interstitial - etiology
MDA5‐associated interstitial lung disease
Myositis
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Description
Summary:Anti‐MDA5‐associated dermatomyositis (MDA5‐associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly progressive interstitial lung disease (RP‐ILD). We report two cases of MDA5‐associated DM with fatal outcome in one of the patients, despite ‘aggressive triple therapy’ for RP‐ILD.
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.14789