C-Glycosylation enabled by N-(glycosyloxy)acetamides

The C-glycosylation of C-nucleophiles including allyltrimethylsilane, silyl enol ethers and phenols with N-(glycosyloxy)acetamides as glycosyl donors has been realized. This protocol provides a convenient and practical route for the synthesis of alkyl C-glycosides and aryl 2-deoxy-β-C-glycosides und...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2020-04, Vol.18 (16), p.3043-3046
Main Authors: Liu, Miao, Li, Bo-Han, Li, Tian, Wu, Xia, Liu, Meng, Xiong, De-Cai, Ye, Xin-Shan
Format: Article
Language:English
Subjects:
Aromatic compounds
Donors (electronic)
Ethers
Glycosides
Glycosylation
Nucleophiles
Phenols
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Summary:The C-glycosylation of C-nucleophiles including allyltrimethylsilane, silyl enol ethers and phenols with N-(glycosyloxy)acetamides as glycosyl donors has been realized. This protocol provides a convenient and practical route for the synthesis of alkyl C-glycosides and aryl 2-deoxy-β-C-glycosides under mild reaction conditions.
ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob00561d