Stimuli-responsive nano-assemblies for remotely controlled drug delivery

• Published in: Journal of controlled release 2020-06, Vol.322, p.566-592
• Main Authors: Li, Fangyuan, Qin, Yu, Lee, Jiyoung, Liao, Hongwei, Wang, Nan, Davis, Thomas P., Qiao, Ruirui, Ling, Daishun
• Format: Article
• Language: English
• Subjects: Bio-cleanable nano-systems; Controlled drug delivery; Nano-assemblies; Stimuli-responsiveness
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2020.03.051

Stimuli-responsive nano-assemblies are emerging as promising drug delivery systems (DDSs) with spatial and temporal tenability, which can undergo structural transition for controlled drug release upon excitation by either exogenous or endogenous stimuli. Particularly, exogenous stimuli-responsive nano-assemblies based remotely controlled DDSs, have received much attention due to their accuracy and reliability realized by tunable exogenous triggers such as light, magnetic field, or temperature. In this review, we will briefly introduce the current state-of-the-art technologies of nano-assembly synthesis and summarize the recent advances in remotely controlled nano-assembly-based DDSs activated by different exogenous stimuli or endogenous/exogenous dual-stimuli. Furthermore, the pioneering progress in bio-cleanable stimuli-responsive nano-assemblies that holds great relevance to clinical translation will be described. Finally, we will conclude with our perspectives on current issues and future development of this field. The objective of this review is to outline current advances of nano-assemblies as remotely controlled DDSs, in hopes of accelerating the future development of intelligent nanomedicines. The current state-of-the-art technologies for nano-assemblies construction, and their applications in remotely controlled nano-assembly-based DDSs. [Display omitted] •Stimuli-responsive nano-assemblies are promising drug delivery systems for controlled drug release.•Nano-assemblies responsive to exogenous stimuli are employed for remotely controlled drug delivery.•The properties of the nano-assembly-based drug delivery systems are dependent on stimuli-triggered structural transition.•Bio-cleanable stimuli-responsive nano-assemblies hold great potential for clinical translation.