StarD13: a potential star target for tumor therapeutics

StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is either downregulated or completely inhibited, depending on the tumor type. As su...

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Bibliographic Details
Published in:Human cell : official journal of Human Cell Research Society 2020-07, Vol.33 (3), p.437-443
Main Authors: Jaafar, Leila, Chamseddine, Zeinab, El-Sibai, Mirvat
Format: Article
Language:English
Subjects:
Actin
Amino Acid Sequence
Apoptosis
Biomedical and Life Sciences
Cell Biology
Cell survival
Down-Regulation
Genes, Tumor Suppressor
GTPase-Activating Proteins - chemistry
GTPase-Activating Proteins - genetics
GTPase-Activating Proteins - metabolism
Guanosine triphosphatases
Gynecology
Humans
Life Sciences
Metastases
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Oncology
p53 Protein
Proteins
Reproductive Medicine
Review Article
rho GTP-Binding Proteins
Stem Cells
Surgery
Tumor suppressor genes
Tumor Suppressor Protein p53
Tumor Suppressor Proteins - chemistry
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Tumors
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Summary:StarD13 is a tumor suppressor and a GTPase activating protein (GAP) for Rho GTPases. Thus, StarD13 regulates cell survival pathways and induces apoptosis in a p53-dependent and independent manners. In tumors, StarD13 is either downregulated or completely inhibited, depending on the tumor type. As such, and through the dysregulation of Rho GTPases, this affects adhesion dynamics, actin dynamics, and leads to an increase or a decrease in tumor metastasis depending on the tumor grade and type. Being a key regulatory protein, StarD13 is a potential promising candidate for therapeutic approaches. This paper reviews the key characteristics of this protein and its role in tumor malignancies.
ISSN:1749-0774
0914-7470
1749-0774
DOI:10.1007/s13577-020-00358-2