REPORT - CYP2D64 null allele frequency in sixteen Pakistani ethnic groups

CYP2D6 belongs to a family of Cytochrome P450 and is involved in metabolism of a number of commonly prescribed drugs. This study was designed to identify *4 allelic frequency of CYP2D6 in Pakistani population. The ethno-geographic variations in the CYP2D6 alleles are responsible for varied expressio...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2020-03, Vol.33 (2), p.739-743
Main Authors: Ullah, Anwar, Riaz, Sana, Siddiqi, Saima, Mazhar, Kehkashan, Mansoor, Atika
Format: Article
Language:English
Subjects:
Cytochrome P-450 CYP2D6 - genetics
Ethnic Groups - genetics
Gene Frequency - genetics
Humans
Loss of Function Mutation - genetics
Pakistan - ethnology
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Summary:CYP2D6 belongs to a family of Cytochrome P450 and is involved in metabolism of a number of commonly prescribed drugs. This study was designed to identify *4 allelic frequency of CYP2D6 in Pakistani population. The ethno-geographic variations in the CYP2D6 alleles are responsible for varied expression of this enzyme and thus influence the metabolic rate and efficacy of prescribed drugs. In total, 976 volunteers belonging to 16 different ethnic groups of Pakistan were screened for CYP2D6*4 polymorphism. The *4 allele was detected in all the ethnic groups with varied frequency ranging from 3.73%-13.64% and an overall average of 7.22% in different ethnic groups of the population. Maximum frequency was detected in northern Pakistani population including Meo (13.64%), Punjabi (11.96%) and Pathan (10.42%). Low frequency (
ISSN:1011-601X