Memory-related process in physiological status and alzheimer’s disease

Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds...

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Bibliographic Details
Published in:Molecular biology reports 2020-06, Vol.47 (6), p.4651-4657
Main Authors: Fotuhi, Seyedeh Nahid, Khalaj-Kondori, Mohammad, Feizi, Mohammad Ali Hoseinpour, Talebi, Mahnaz
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Alzheimer's disease
Animal Anatomy
Animal Biochemistry
Animals
Biomedical and Life Sciences
Brain - physiology
Cognitive ability
Dentate gyrus
Disease Models, Animal
Glutamatergic transmission
Granule cells
Hippocampus
Hippocampus - physiology
Histology
Humans
Life Sciences
Memory
Memory - physiology
Morphology
Nerve Net - physiology
Neurodegenerative diseases
Neurogenesis
Neuronal Plasticity - physiology
Neurons - physiology
Review
Synaptic plasticity
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Summary:Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds with synaptic plasticity to process all the developing stages required to successful maturation and functional integration, whereby the memory context is ready to leave the hippocampus toward cortex network through consolidation process, for being installed and run the memory disk forever. However, in Alzheimer’s disease, brain deal with subtle deadly progressive loss of synapsis, neuronal dysfunction and ultimately network failure, resulting in memory decay and cognitive decline—concluding that AD destroys memory formation related-pathways.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-020-05438-y