Polyurethane-modified graphene oxide composite bilayer wound dressing with long-lasting antibacterial effect

• Published in: Materials Science & Engineering C 2020-06, Vol.111, p.110833-110833, Article 110833
• Main Authors: Jian, Zhiwen, Wang, He, Liu, Menglong, Chen, Siyao, Wang, Zhanhua, Qian, Wei, Luo, Gaoxing, Xia, Hesheng
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Bandages; Bilayers; Biocompatibility; Broad spectrum antibacterial; Cell Death - drug effects; Cell Survival - drug effects; Fluorescence; Graphene; Graphite - pharmacology; Guanidine hydrochloride; HaCaT Cells; Humans; Lipid Bilayers - chemistry; Long-lasting antibacterial; Male; Materials science; Membrane permeability; Membranes; Mice, Inbred BALB C; Phase separation; Photoelectron Spectroscopy; Plastics - pharmacology; Polyurethane; Polyurethane resins; Polyurethanes - pharmacology; Porosity; Properties (attributes); Shaking; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; TPU; Urethane thermoplastic elastomers; Water vapor; Wound dressing; Wound healing; Wound Healing - drug effects
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2020.110833

In order to obtain a novel multifunctional wound dressing with good water vapor permeability and long-lasting antibacterial properties, a skin-like thermoplastic polyurethane (TPU) bilayer membrane containing self-made polyhexamethylene guanidine hydrochloride (PHMG) grafted graphene oxide (MGO) was prepared by non-solvent phase separation and particle filtration. The antibacterial properties and wound-healing ability of TPU, GO-TPU, MGO-TPU composite porous membrane are systematically compared. The results show that with the incorporation of MGO, the porous MGO-TPU membrane exhibits good biocompatibility, excellent water vapor transmission properties, and long-lasting broad-spectrum antibacterial properties (the antibacterial property remains unchanged for 30 days under continuously shaking and washing). The wound healing results for mouse model show that MGO-TPU could significantly accelerate the healing rate of wounds as it provides a sterile environment and also promotes the formation of re-epithelialization during wound healing. [Display omitted] •Successful preparation of modified graphene oxide (MGO) by PHMG modified graphene oxide.•Successful preparation of bilayer wound dressing by non-solvent phase separation and particle filtration.•MGO-TPU composite wound dressing shows good biocompatibility and long-lasting broad-spectrum antibacterial properties•MGO0.5-TPU shows excellent ability to accelerate wound healing by accelerating epithelial regeneration.