Association of PCSK1 gene polymorphisms with abdominal fat content in broilers

Protein proteolytic enzymes (Proprotein Convertase, PC) is a Ca2+‐dependent serine protease family, whose main function is to cleave precursors of biologically inactive proteins or peptide chains into active functional molecules. Proprotein convertase subtilisin/kexin type 1 (PCSK1) gene is mainly e...

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Bibliographic Details
Published in:Animal science journal 2020-01, Vol.91 (1), p.e13371-n/a
Main Authors: Zhou, Jiamei, Yang, Lili, Yu, Jiaqiang, Zhang, Ke, Xu, Zichun, Cao, Zhiping, Luan, Peng, Li, Hui, Zhang, Hui
Format: Article
Language:English
Subjects:
Abdomen
abdominal fat
Abdominal Fat - metabolism
Animals
Association analysis
broilers
Calcium
Calcium ions
Chickens - genetics
Dietary fiber
Gene polymorphism
Genetic Association Studies
Kexin
Lipid Metabolism - genetics
Nucleotides
PCSK1 gene
Polymorphism
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Population studies
Populations
Proprotein Convertase 1 - genetics
Proprotein convertases
Proteins
Proteolysis
Proteolytic enzymes
Serine
Serine proteinase
Single-nucleotide polymorphism
Subtilisin
Weights & measures
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Summary:Protein proteolytic enzymes (Proprotein Convertase, PC) is a Ca2+‐dependent serine protease family, whose main function is to cleave precursors of biologically inactive proteins or peptide chains into active functional molecules. Proprotein convertase subtilisin/kexin type 1 (PCSK1) gene is mainly expressed in nerve and endocrine tissues. In this study, PCSK1 was selected as an important candidate gene for abdominal fat content in broilers. We cloned the exon region of chicken PCSK1 gene and found six single‐nucleotide polymorphisms (SNPs). Association analysis was carried out and we found that the polymorphisms of these six SNPs were significantly associated with abdominal fat content in G19 and G20 populations. Five of these SNPs were significantly associated with abdominal fat content in G19 and G20 combined population. The polymorphism of these five SNPs was significantly correlated with the abdominal fat content of AA broilers. Together, our study demonstrated that c.927T>C, c.1880C>T, c.*900G>A, and c.*1164C>T were significantly associated with abdominal fat content in populations used in this study, which means that these SNPs in PCSK1 gene could be used as candidate markers to select lean broiler lines.
ISSN:1344-3941
1740-0929
DOI:10.1111/asj.13371