Coronary artery bypass surgery independently associates with retinal vascular oxygen saturation

Purpose The retinal vasculature is the only part of the microcirculation that can be directly studied by non‐invasive imaging. Based on the hypothesis that the systemic circulation is reflected in retinal vessels, we investigated if coronary artery bypass grafting (CABG) is related to changes in ret...

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Published in:Acta ophthalmologica (Oxford, England) England), 2020-11, Vol.98 (7), p.709-715
Main Authors: Dinesen, Sebastian, Jensen, Pia S., Bloksgaard, Maria, Mey, Jo De, S.Lindholt, Jes, Rasmusssen, Lars M., Grauslund, Jakob
Format: Article
Language:English
Subjects:
Blood vessels
Bypass
CABG
Cardiovascular diseases
Cataracts
Coronary artery
Coronary vessels
Heart surgery
imaging
Oxygen
oxygen metabolism
Oxygen saturation
Regression analysis
Retina
retinal microcirculation
retinal oximetry
Stents
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Summary:Purpose The retinal vasculature is the only part of the microcirculation that can be directly studied by non‐invasive imaging. Based on the hypothesis that the systemic circulation is reflected in retinal vessels, we investigated if coronary artery bypass grafting (CABG) is related to changes in retinal vascular oxygen saturation (rSatO2). Methods Retinal metabolism was evaluated by Oxymap T1, which simultaneously captures two retinal images at different wavelengths measuring the retinal arteriolar (raSatO2) and venular (rvSatO2) oxygen saturation. Three to 4 days after surgery, we measured the median rSatO2 after CABG in 38 patients and in 39 healthy controls (operated for cataract). Results Coronary artery bypass grafting patients had higher raSatO2 (median ± standard deviation 93.1 ± 6.7% versus 90.5 ± 11.2%, p = 0.001) and rvSatO2 (57.4 ± 8.3% versus 53.5 ± 15.4%, p = 0.048) compared to healthy controls. In multivariable linear regression models, raSatO2 independently associated with CABG (coefficient + 3.6% in CABG patients, p = 0.007), and rvSatO2 correlated with gender (coefficient + 9.4% for females, p = 0.001) and CABG (coefficient + 8.2% in patients with CABG, p = 0.001). Conclusions Comparing patients with and without cardiovascular disease, raSatO2 and rvSatO2 positively and independently associated with CABG, suggesting their potential as non‐invasive markers for coronary large artery disease.
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.14444