Tumor-associated macrophage infiltration and prognosis in colorectal cancer: systematic review and meta-analysis

Background Tumor-associated macrophages (TAMs) are key components of colorectal cancer (CRC) microenvironment, but their role in CRC prognosis is not fully defined. Objective This study aimed to evaluate prognostic value of different types and distribution of TAMs in CRC. Methods Total 27 studies wi...

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Bibliographic Details
Published in:International journal of colorectal disease 2020-07, Vol.35 (7), p.1203-1210
Main Authors: Li, Jinyuan, Li, Linhai, Li, Yuejin, Long, Yaxin, Zhao, Quan, Ouyang, Yiming, Bao, Weimin, Gong, Kunmei
Format: Article
Language:English
Subjects:
Analysis
CD163 antigen
Colon cancer
Colorectal cancer
Colorectal carcinoma
Gastroenterology
Hepatology
Infiltration
Internal Medicine
Macrophages
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Meta-analysis
Metastases
Mismatch repair
Original Article
Proctology
Prognosis
Stroma
Surgery
Tumors
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Summary:Background Tumor-associated macrophages (TAMs) are key components of colorectal cancer (CRC) microenvironment, but their role in CRC prognosis is not fully defined. Objective This study aimed to evaluate prognostic value of different types and distribution of TAMs in CRC. Methods Total 27 studies with 6115 patients were searched from PubMed and Embase and analyzed to determine the association between TAMs, including distinct TAM subsets and infiltration location, and CRC survival. The prognostic impact of TAMs on CRC was further stratified by tumor type and mismatch repair system (MMR) status. Results A pooled analysis indicated that high density of TAMs in CRC tissue was significantly associated with favorable 5-year overall survival (OS) but not with disease-free survival (DFS). CD 68 + TAM subset correlated with better 5-year OS, while neither CD68 + NOS2 + M1 subset nor CD163 + M2 subset was correlated with 5-year OS. Increased CD68 + TAM infiltration in tumor stroma but not in tumor islet predicted improved 5-year OS. Stratification by tumor type and MMR status showed that in colon cancer or MMR-proficient CRC, elevated TAM density was associated with better 5-year OS. Conclusions High infiltration of CD68 + TAMs could be a favorable prognostic marker in CRC. Future therapies stimulating CD68 + TAM infiltration may be promising in CRC treatment.
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-020-03593-z