Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer

Purpose To evaluate the effect of scheduled intravenous acetaminophen administration versus nonsteroidal anti-inflammatory drugs on postoperative pain and short-term outcomes after esophagectomy. Methods The subjects of this study were 150 consecutive patients who underwent esophagectomy for esophag...

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Published in:Surgery today (Tokyo, Japan) Japan), 2020-10, Vol.50 (10), p.1168-1175
Main Authors: Kawakami, Jiro, Abe, Tetsuya, Higaki, Eiji, Hosoi, Takahiro, Fukaya, Masahide, Komori, Koji, Ito, Seiji, Nakatochi, Masahiro, Nagino, Masato, Shimizu, Yasuhiro
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Medicine & Public Health
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Surgery
Surgical Oncology
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cited_by cdi_FETCH-LOGICAL-c455t-526517d43cbc3ba3638bdbbe97f81fa358d73f2f30bb5dcffb9ab05764db010e3
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container_title Surgery today (Tokyo, Japan)
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creator Kawakami, Jiro
Abe, Tetsuya
Higaki, Eiji
Hosoi, Takahiro
Fukaya, Masahide
Komori, Koji
Ito, Seiji
Nakatochi, Masahiro
Nagino, Masato
Shimizu, Yasuhiro
description Purpose To evaluate the effect of scheduled intravenous acetaminophen administration versus nonsteroidal anti-inflammatory drugs on postoperative pain and short-term outcomes after esophagectomy. Methods The subjects of this study were 150 consecutive patients who underwent esophagectomy for esophageal cancer. Seventy-seven patients received scheduled intravenous acetaminophen and the other 73 received NSAIDs enterally for postoperative pain management. We compared the postoperative pain and short-term outcomes between the groups. Inverse probability of treatment weighting (IPTW) based on propensity scores was used to control for selection bias. Results The visual analog scale (VAS) of postoperative pain was lower in the acetaminophen group than in the NSAIDs group, based on the mean values of chest VAS on postoperative days (PODs) 0, 4, 5, and 6 and the mean values of abdomen VAS on PODs 4, 5, and 6. The incidence of anastomotic leakage and postoperative delirium was lower in the acetaminophen group than in the NSAIDs group (anastomotic leakage, odds ratio (OR) 0.3, p  = 0.01; postoperative delirium, OR 0.19, p 
doi_str_mv 10.1007/s00595-020-02001-x
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Methods The subjects of this study were 150 consecutive patients who underwent esophagectomy for esophageal cancer. Seventy-seven patients received scheduled intravenous acetaminophen and the other 73 received NSAIDs enterally for postoperative pain management. We compared the postoperative pain and short-term outcomes between the groups. Inverse probability of treatment weighting (IPTW) based on propensity scores was used to control for selection bias. Results The visual analog scale (VAS) of postoperative pain was lower in the acetaminophen group than in the NSAIDs group, based on the mean values of chest VAS on postoperative days (PODs) 0, 4, 5, and 6 and the mean values of abdomen VAS on PODs 4, 5, and 6. The incidence of anastomotic leakage and postoperative delirium was lower in the acetaminophen group than in the NSAIDs group (anastomotic leakage, odds ratio (OR) 0.3, p  = 0.01; postoperative delirium, OR 0.19, p  &lt; 0.01). Conclusion Scheduled intravenous acetaminophen administration is effective and feasible for the postoperative pain management of patients undergoing esophagectomy and may be associated with a lower incidence of anastomotic leakage and postoperative delirium.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-020-02001-x</identifier><identifier>PMID: 32300859</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Medicine ; Medicine &amp; Public Health ; Original Article ; Surgery ; Surgical Oncology</subject><ispartof>Surgery today (Tokyo, Japan), 2020-10, Vol.50 (10), p.1168-1175</ispartof><rights>Springer Nature Singapore Pte Ltd. 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-526517d43cbc3ba3638bdbbe97f81fa358d73f2f30bb5dcffb9ab05764db010e3</citedby><cites>FETCH-LOGICAL-c455t-526517d43cbc3ba3638bdbbe97f81fa358d73f2f30bb5dcffb9ab05764db010e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32300859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawakami, Jiro</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Higaki, Eiji</creatorcontrib><creatorcontrib>Hosoi, Takahiro</creatorcontrib><creatorcontrib>Fukaya, Masahide</creatorcontrib><creatorcontrib>Komori, Koji</creatorcontrib><creatorcontrib>Ito, Seiji</creatorcontrib><creatorcontrib>Nakatochi, Masahiro</creatorcontrib><creatorcontrib>Nagino, Masato</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><title>Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose To evaluate the effect of scheduled intravenous acetaminophen administration versus nonsteroidal anti-inflammatory drugs on postoperative pain and short-term outcomes after esophagectomy. Methods The subjects of this study were 150 consecutive patients who underwent esophagectomy for esophageal cancer. Seventy-seven patients received scheduled intravenous acetaminophen and the other 73 received NSAIDs enterally for postoperative pain management. We compared the postoperative pain and short-term outcomes between the groups. Inverse probability of treatment weighting (IPTW) based on propensity scores was used to control for selection bias. Results The visual analog scale (VAS) of postoperative pain was lower in the acetaminophen group than in the NSAIDs group, based on the mean values of chest VAS on postoperative days (PODs) 0, 4, 5, and 6 and the mean values of abdomen VAS on PODs 4, 5, and 6. The incidence of anastomotic leakage and postoperative delirium was lower in the acetaminophen group than in the NSAIDs group (anastomotic leakage, odds ratio (OR) 0.3, p  = 0.01; postoperative delirium, OR 0.19, p  &lt; 0.01). Conclusion Scheduled intravenous acetaminophen administration is effective and feasible for the postoperative pain management of patients undergoing esophagectomy and may be associated with a lower incidence of anastomotic leakage and postoperative delirium.</description><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Original Article</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UcluFDEQtRCITAI_wAH5mBwayu12L8coQIgUkUPC2fJSnumo2x5sd5T5nPwpnkzCkUPJpaq3qPwI-cTgCwPoviYAMYgKatgXsOrxDVmxhrdV3TP-lqxgaFjF6oEdkeOU7gHqpgd4T454zQF6MazI063ZoF0mtHT0OaoH9GFJVBnMah592G7Q0weMqQx98CljDKNVE1U-j9Xo3aTmWeUQd9TGZZ3o6a_b86tv6Yy6EKnGXAg0bULMVelmGpZswozFwe03mIqDWqPJYd49U14nxcIobzB-IO-cmhJ-fHlPyO8f3-8uflbXN5dXF-fXlWmEyJWoW8E623CjDdeKt7zXVmscOtczp7jobcdd7ThoLaxxTg9Kg-jaxmpggPyEnB50tzH8WTBlOY_J4DQpj-VLZM0HNnScDW2B1geoiSGliE5u4ziruJMM5D4aeYhGlljkczTysZA-v-gvekb7j_KaRQHwAyCVlV9jlPdhib7c_D_ZvwGcn48</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Kawakami, Jiro</creator><creator>Abe, Tetsuya</creator><creator>Higaki, Eiji</creator><creator>Hosoi, Takahiro</creator><creator>Fukaya, Masahide</creator><creator>Komori, Koji</creator><creator>Ito, Seiji</creator><creator>Nakatochi, Masahiro</creator><creator>Nagino, Masato</creator><creator>Shimizu, Yasuhiro</creator><general>Springer Singapore</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201001</creationdate><title>Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer</title><author>Kawakami, Jiro ; Abe, Tetsuya ; Higaki, Eiji ; Hosoi, Takahiro ; Fukaya, Masahide ; Komori, Koji ; Ito, Seiji ; Nakatochi, Masahiro ; Nagino, Masato ; Shimizu, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-526517d43cbc3ba3638bdbbe97f81fa358d73f2f30bb5dcffb9ab05764db010e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Original Article</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakami, Jiro</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Higaki, Eiji</creatorcontrib><creatorcontrib>Hosoi, Takahiro</creatorcontrib><creatorcontrib>Fukaya, Masahide</creatorcontrib><creatorcontrib>Komori, Koji</creatorcontrib><creatorcontrib>Ito, Seiji</creatorcontrib><creatorcontrib>Nakatochi, Masahiro</creatorcontrib><creatorcontrib>Nagino, Masato</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakami, Jiro</au><au>Abe, Tetsuya</au><au>Higaki, Eiji</au><au>Hosoi, Takahiro</au><au>Fukaya, Masahide</au><au>Komori, Koji</au><au>Ito, Seiji</au><au>Nakatochi, Masahiro</au><au>Nagino, Masato</au><au>Shimizu, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>50</volume><issue>10</issue><spage>1168</spage><epage>1175</epage><pages>1168-1175</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose To evaluate the effect of scheduled intravenous acetaminophen administration versus nonsteroidal anti-inflammatory drugs on postoperative pain and short-term outcomes after esophagectomy. Methods The subjects of this study were 150 consecutive patients who underwent esophagectomy for esophageal cancer. Seventy-seven patients received scheduled intravenous acetaminophen and the other 73 received NSAIDs enterally for postoperative pain management. We compared the postoperative pain and short-term outcomes between the groups. Inverse probability of treatment weighting (IPTW) based on propensity scores was used to control for selection bias. Results The visual analog scale (VAS) of postoperative pain was lower in the acetaminophen group than in the NSAIDs group, based on the mean values of chest VAS on postoperative days (PODs) 0, 4, 5, and 6 and the mean values of abdomen VAS on PODs 4, 5, and 6. The incidence of anastomotic leakage and postoperative delirium was lower in the acetaminophen group than in the NSAIDs group (anastomotic leakage, odds ratio (OR) 0.3, p  = 0.01; postoperative delirium, OR 0.19, p  &lt; 0.01). Conclusion Scheduled intravenous acetaminophen administration is effective and feasible for the postoperative pain management of patients undergoing esophagectomy and may be associated with a lower incidence of anastomotic leakage and postoperative delirium.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32300859</pmid><doi>10.1007/s00595-020-02001-x</doi><tpages>8</tpages></addata></record>
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Medicine & Public Health
Original Article
Surgery
Surgical Oncology
title Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer
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