Preparation and evaluation of curcumin grafted hyaluronic acid modified pullulan polymers as a functional wound dressing material

[Display omitted] •A series of curcumin grafted hyaluronic acid modified pullulan (Cur-HA-SPu) polymers were synthesized and characterized.•Cur-HA-SPu polymers had a good biocompatibility.•Cur-HA-SPu polymers had anti-microbial activities and antioxidant properties.•Cur-HA-SPu films significantly pr...

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Bibliographic Details
Published in:Carbohydrate polymers 2020-06, Vol.238, p.116195-116195, Article 116195
Main Authors: Duan, Yumeng, Li, Kaiyue, Wang, Huangwei, Wu, Tong, Zhao, Yafei, Li, Haiying, Tang, Hongbo, Yang, Wenzhi
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antioxidants - pharmacology
Bandages
Biocompatible Materials - chemistry
Cell Line
Cell Proliferation - drug effects
Cell Survival - drug effects
Curcumin
Curcumin - pharmacology
Escherichia coli - drug effects
Glucans - chemistry
Hyaluronic acid
Hyaluronic Acid - chemistry
Mice
Polysaccharide
Pullulan
Rats
Rats, Wistar
Staphylococcus aureus - drug effects
Wound healing
Wound Healing - drug effects
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Summary:[Display omitted] •A series of curcumin grafted hyaluronic acid modified pullulan (Cur-HA-SPu) polymers were synthesized and characterized.•Cur-HA-SPu polymers had a good biocompatibility.•Cur-HA-SPu polymers had anti-microbial activities and antioxidant properties.•Cur-HA-SPu films significantly promoted wound healing. Curcumin grafted hyaluronic acid modified pullulan polymers (Cur-HA-SPu) by chemical conjugation was designed and prepared, and its film may be used to accelerate wound healing and help to fight infection. The synthesis of Cur-HA-SPu polymer was characterized by FT-IR, 1H NMR and DSC. Cur-HA-SPu film has a higher swelling ratio than that of HA-SPu film. Moreover, the good biocompatibility of Cur-HA-SPu polymer was confirmed by skin irritation, cytotoxicity and hemolysis tests. Compared to Cur, the MTT and proliferation test carried out in L929 cells revealed that Cur-HA-SPu polymer showed no cytotoxicity and enhanced cell proliferation. Cur-HA-SPu polymer exhibited a certain bactericidal activity against E. coli and S. aureus. Furthermore, the materials showed antioxidant activity when DPPH method determined. Wound healing study using wistar rat model demonstrated that Cur-HA-SPu film obtained better wound healing result than that of HA-SPu film or natural healing. The above results suggest that Cur-HA-SPu film is a promising and safety formulation for accelerating skin wound healing.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2020.116195