The CSF-contacting nucleus regulates learning and memory through synaptic connections with the hippocampus

•The learning and memory abilities of CSF-contacting nucleus “knockout” rats was impaired.•The CSF-contacting nucleus has synaptic connections with the hippocampus.•The CSF-contacting nucleus may participate in the regulation of learning and memory by regulating hippocampal 5-HT. The cerebrospinal f...

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Bibliographic Details
Published in:Neuroscience letters 2020-05, Vol.728, p.134972-134972, Article 134972
Main Authors: Li, Qing, Liu, He, Zhang, Licai, Zhang, Hongxing, Zhou, Fang
Format: Article
Language:English
Subjects:
5-HT
Animals
CSF-contacting nucleus
Hippocampus
Hippocampus - physiology
Learning - physiology
Learning and memory
Male
Memory - physiology
Neurons - physiology
Pain - physiopathology
Rats, Sprague-Dawley
Serotonin - cerebrospinal fluid
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Summary:•The learning and memory abilities of CSF-contacting nucleus “knockout” rats was impaired.•The CSF-contacting nucleus has synaptic connections with the hippocampus.•The CSF-contacting nucleus may participate in the regulation of learning and memory by regulating hippocampal 5-HT. The cerebrospinal fluid (CSF)-contacting nucleus is a special nucleus. To study the mechanism of the CSF-contacting nucleus in learning and memory, we used classic retrograde tracing methods to observe the synaptic connections between the CSF-contacting nucleus and the hippocampus. By injecting cholera toxin B subunit (CB) - saporin (SAP) into the lateral ventricle of animals to exclusively damage this nucleus, a mature CSF-contacting nucleus-deficient model animal was established. Then, the changes in learning and memory behaviors in animals with "damage" or "compensation" after damage to the CSF-contacting nucleus were studied. The results showed that learning and memory abilities in animals decreased significantly after the destruction of the CSF-contacting nucleus, accompanied by a decrease in 5-HT concentrations in hippocampus. However, after compensating for 5-HT in the hippocampus continuously, the learning and memory abilities of the animals were significantly improved. This study suggests that the CSF-contacting nucleus may participate in the regulation of learning and memory through direct synaptic connections with the hippocampus.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2020.134972