High levels of cathepsin S and cystatin C in patients with fibromyalgia syndrome

Objectives Although the etiopathogenesis of fibromyalgia syndrome (FM) is not yet clear, central sensitization is thought to be responsible for the pathogenesis of FM. The aim of this study was to compare the serum cathepsin S (CatS) and cystatin C (CysC) levels between patients with FM and healthy...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2020-07, Vol.23 (7), p.966-969
Main Authors: Kocak, Ibrahim, Hizmetli, Sami, Tas, Ayça, Karadag, Ahmet, Zontul, Cemile, Silig, Yavuz
Format: Article
Language:English
Subjects:
Body mass index
Cathepsin S
Cystatin C
Fibromyalgia
pain
Patients
Rehabilitation
Statistical analysis
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Summary:Objectives Although the etiopathogenesis of fibromyalgia syndrome (FM) is not yet clear, central sensitization is thought to be responsible for the pathogenesis of FM. The aim of this study was to compare the serum cathepsin S (CatS) and cystatin C (CysC) levels between patients with FM and healthy control subjects. Methods This study was conducted in the Physical Medicine and Rehabilitation Clinic between January 2019 and October 2019. The study included 145 FM patients newly diagnosed with primary FM according to the 2010 American College of Rheumatology criteria and 129 healthy volunteers. The age, gender, and body mass index (BMI) of the participants were recorded. Venous blood samples were collected from both groups for the measurement of the levels of serum CatS and CysC. The functional status of FM patients was evaluated using the Fibromyalgia Impact Questionnaire (FIQ). Results No statistically significant difference was determined between the patient and control groups in terms of age, gender, and BMI (P > .05). A comparison of the serum CatS and CysC levels of the FM and control groups revealed a statistically significant difference (P = .001). No correlation was determined between FIQ and serum CatS and CysC levels (P > .05). Conclusion Serum CatS and CysC levels were found to be higher in FM patients. However, there was no correlation between the functional status of FM patients and serum CatS and CysC levels. These results can be of guidance for further clinical studies of the etiopathogenesis and treatment of FM.
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.13840