Mid-term predictive value of calciprotein particles in maintenance hemodialysis patients based on a gel-filtration assay

Calciprotein particles (CPPs), nano-aggregates containing fetuin-A-bound calcium-phosphate, are associated with aortic stiffness and coronary calcification in maintenance hemodialysis patients. A novel gel-filtration assay can detect low-density small CPPs, which are actually a major form of circula...

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Bibliographic Details
Published in:Atherosclerosis 2020-06, Vol.303, p.46-52
Main Authors: Gatate, Yodo, Nakano, Shintaro, Mizuno, Yosuke, Muramatsu, Toshihiro, Senbonmatsu, Takaaki, Nishimura, Shigeyuki, Kono, Rika, Kaneko, Keiko, Miura, Yutaka, Kuro-o, Makoto
Format: Article
Language:English
Subjects:
Calciprotein particle (CPP)
Gel filtration method
Vascular calcification
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Summary:Calciprotein particles (CPPs), nano-aggregates containing fetuin-A-bound calcium-phosphate, are associated with aortic stiffness and coronary calcification in maintenance hemodialysis patients. A novel gel-filtration assay can detect low-density small CPPs, which are actually a major form of circulating CPPs in vivo. We sought to investigate whether circulating CPP levels measured by gel-filtration method would accurately predict hard endpoints in maintenance hemodialysis patients. This study used a prospective, multicenter, longitudinal, and observational design. One-hundred eight patients enrolled in this study were followed-up for about 2 years. We reported all-cause death and cardiovascular events, which included major adverse cardiac, cerebrovascular, and limb events. Kaplan-Meier analysis showed no significant difference between patients with the higher (>median) and lower (
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2020.03.016