Retinal Toxicity in a Patient on Pentosan Polysulfate Sodium

Pentosan Polysulfate Sodium (PPS) is commonly used in the treatment of interstitial cystitis/bladder pain syndrome. Recently there have been reported cases of retinal toxicity associated with long-term PPS use. We present a case of a 42-year-old female taking PPS for the last 10 years who was found...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2020-07, Vol.141, p.e41-e42
Main Authors: Wingelaar, Maxwell J., Raevis, Joseph J., Conlin, Karina A., Stepien, Kimberly E.
Format: Article
Language:English
Subjects:
Adult
Cystitis, Interstitial - drug therapy
Female
Humans
Pentosan Sulfuric Polyester - adverse effects
Pentosan Sulfuric Polyester - therapeutic use
Retinal Diseases - chemically induced
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Summary:Pentosan Polysulfate Sodium (PPS) is commonly used in the treatment of interstitial cystitis/bladder pain syndrome. Recently there have been reported cases of retinal toxicity associated with long-term PPS use. We present a case of a 42-year-old female taking PPS for the last 10 years who was found to have signs of retinal toxicity, but was completely asymptomatic. PPS was discontinued after these retinal findings were discovered.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2020.04.006