US-guided laser treatment of parathyroid adenomas

To determine the clinical efficacy of laser ablation for the tredatment of primary hyperparathyroidism (pHPT). Twelve patients with pHPT were treated with laser ablation. Energy was administered by means of 1.5 m optical fibers percutaneously placed into the target via 21 G needles. A laser ablation...

Full description

Saved in:
Bibliographic Details
Published in:International journal of hyperthermia 2020-01, Vol.37 (1), p.366-372
Main Authors: Appelbaum, Liat, Goldberg, Shraga Nahum, Ierace, Tiziana, Mauri, Giovanni, Solbiati, Luigi
Format: Article
Language:English
Subjects:
Laser ablation
parathyroid ablation
parathyroid adenoma
primary hyperparathyroidism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To determine the clinical efficacy of laser ablation for the tredatment of primary hyperparathyroidism (pHPT). Twelve patients with pHPT were treated with laser ablation. Energy was administered by means of 1.5 m optical fibers percutaneously placed into the target via 21 G needles. A laser ablation unit (EchoLaser X4, Esaote) applied 3 W power for 400-600 s/fiber/insertion to a total 3600-9000 Joules of energy. Patient serum parathyroid hormone (PTH) and calcium levels were checked at baseline and thereafter every 6 months. Patients were followed-up for 2 years with serologic and contrast-enhanced ultrasound. Therapeutic success was defined as normal PTH and calcium levels together with disappearance of nodule-related symptoms. All procedures were performed in single session. Immediately following ablation, contrast enhanced ultrasound confirmed that all but one target had become avascular (technical success rate 11/12; 92%), remaining avascular at all follow-up ultrasound examinations, thereafter. The mean volume of parathyroid nodules decreased from 0.54 cc to 0.36 cc (72.0%). Serum PTH and calcium levels were significantly lower at 1, 12 and 24 m compared to baseline (p 
ISSN:0265-6736
1464-5157
DOI:10.1080/02656736.2020.1750712