Inflammatory biomarkers and dynamics of neutrophil-to-lymphocyte ratio in anaplastic thyroid carcinoma

Purpose Studies have shown that inflammatory biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), are associated with prognosis or treatment efficacy in various cancers. The present study investigated the association be...

Full description

Saved in:
Bibliographic Details
Published in:Endocrine 2020-10, Vol.70 (1), p.115-122
Main Authors: Yamazaki, Haruhiko, Sugino, Kiminori, Matsuzu, Kenichi, Masaki, Chie, Akaishi, Junko, Hames, Kiyomi, Tomoda, Chisato, Suzuki, Akifumi, Uruno, Takashi, Ohkuwa, Keiko, Kitagawa, Wataru, Nagahama, Mitsuji, Masuda, Munetaka, Ito, Koichi
Format: Article
Language:English
Subjects:
Biomarkers
Diabetes
Endocrinology
Humanities and Social Sciences
Inflammation
Internal Medicine
Lymphocytes
Medical prognosis
Medicine
Medicine & Public Health
Monocytes
multidisciplinary
Neutrophils
Original Article
Prognosis
Science
Thyroid cancer
Thyroid carcinoma
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Studies have shown that inflammatory biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), are associated with prognosis or treatment efficacy in various cancers. The present study investigated the association between the inflammatory biomarkers and dynamics of NLR, and prognosis or disease progression in anaplastic thyroid carcinoma (ATC). Methods This study included 55 patients with ATC who had available complete blood count (CBC) data. Overall survival based on inflammatory biomarker value, and the dynamics of NLR among patients with ATC were investigated. Change in NLR was obtained by subtracting the baseline value from the max value obtained during follow-up period, and we subclassified 51 ATC patients who had follow-up CBC data into the increased group (change of NLR > 5.5) and non-increased group (change of NLR ≤ 5.5). Results There were no significant differences in OS according to baseline NLR, PLR, and LMR values. Among the 51 patients with ATC who had follow-up CBC data, the median OS was 7.7 [95% confidence interval (CI): 5.2–12.1] months in the increased group ( n  = 27), versus 23.5 [95% CI: 13.9–not available] months in the non-increased ( n  = 24) group ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-020-02313-5