Residual platelet reactivity, thrombus burden and myocardial reperfusion in patients treated by PCI after successful pre-hospital fibrinolysis compared to primary PCI

We compared residual platelet reactivity and post PCI atherothrombotic burden using OFDI in patients successfully treated by primary PCI versus pharmacoinvasive approach (PI) defined as PCI after successful pre-hospital fibrinolysis. Despite pre-hospital P2Y12-inhibitor loading dose, high rates of h...

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Published in:Journal of thrombosis and thrombolysis 2020-11, Vol.50 (4), p.858-866
Main Authors: Roule, Vincent, Schwob, Lin, Briet, Clément, Lemaitre, Adrien, Bignon, Mathieu, Ardouin, Pierre, Sabatier, Rémi, Blanchart, Katrien, Beygui, Farzin
Format: Article
Language:English
Subjects:
Blood clots
Cardiology
Drug therapy
Fibrinolysis
Hematology
Medicine
Medicine & Public Health
Patients
Platelets
Reperfusion
Thrombosis
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creator Roule, Vincent
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description We compared residual platelet reactivity and post PCI atherothrombotic burden using OFDI in patients successfully treated by primary PCI versus pharmacoinvasive approach (PI) defined as PCI after successful pre-hospital fibrinolysis. Despite pre-hospital P2Y12-inhibitor loading dose, high rates of high on-treatment platelet reactivity were found at the time of PCI in both groups. Primary PCI patients had higher post stenting thrombus burden and lower rates of final normal myocardial blush grade compared to PI. These findings support the use of a pharmacoinvasive reperfusion strategy especially when primary PCI cannot be timely performed.
doi_str_mv 10.1007/s11239-020-02113-8
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subjects Blood clots
Cardiology
Drug therapy
Fibrinolysis
Hematology
Medicine
Medicine & Public Health
Patients
Platelets
Reperfusion
Thrombosis
title Residual platelet reactivity, thrombus burden and myocardial reperfusion in patients treated by PCI after successful pre-hospital fibrinolysis compared to primary PCI
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