Eccrine porocarcinoma of the head and neck: Meta‐analysis of 120 cases

Background The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck. Methods One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases w...

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Published in:Head & neck 2020-09, Vol.42 (9), p.2644-2659
Main Authors: Le, Nguyen‐Son, Janik, Stefan, Liu, David T., Grasl, Stefan, Faisal, Muhammad, Pammer, Johannes, Schickinger‐Fischer, Bettina, Hamzavi, Jafar‐Sasan, Seemann, Rudolf, Erovic, Boban M.
Format: Article
Language:English
Subjects:
eccrine porocarcinoma
Head and neck
malignant eccrine poroma
Medical prognosis
Meta-analysis
Microsurgery
Patients
prognostic factors
Surgery
Survival
treatment outcome
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Summary:Background The aim of the study is to analyze potential prognostic factors and to evaluate therapy strategies regarding clinical outcome in patients with eccrine porocarcinoma (EPC) of the head and neck. Methods One hundred and sixteen EPC cases from ninety studies and four authors' EPC cases were included in the meta‐analysis. Results At an average follow up of 20.48 months, the 3‐year overall survival and regional recurrence rate were 70.3% and 19.0%, respectively. Patients without surgical treatment had a significantly worse 3‐year overall survival. Mohs microscopic surgery led to significantly less occurrence of regional recurrences compared to wide excision. An ulcerating lesion, high mitotic activity, and lymphovascular invasion were significant prognostic factors. Conclusion Surgical resection is the cornerstone in the therapy of EPC and represents the therapeutic modality that offers the best chance of disease‐free survival. Due to the high probability of recurrence, close follow‐ups are strongly recommended.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26178