Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China

Abstract Data concerning the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic and paucisymptomatic patients are lacking. We report a 3-family cluster of infections involving asymptomatic and paucisymptomatic transmission. Eight of 15 (53%) members from 3 f...

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Bibliographic Details
Published in:The Journal of infectious diseases 2020-06, Vol.221 (12), p.1948-1952
Main Authors: Jiang, Xiao-Lin, Zhang, Xiao-Li, Zhao, Xiang-Na, Li, Cun-Bao, Lei, Jie, Kou, Zeng-Qiang, Sun, Wen-Kui, Hang, Yang, Gao, Feng, Ji, Sheng-Xiang, Lin, Can-Fang, Pang, Bo, Yao, Ming-Xiao, Anderson, Benjamin D, Wang, Guo-Lin, Yao, Lin, Duan, Li-Jun, Kang, Dian-Min, Ma, Mai-Juan
Format: Article
Language:English
Subjects:
Adult
Aged
Asymptomatic
Asymptomatic Infections
Betacoronavirus - genetics
China - epidemiology
Contact Tracing
Coronavirus Infections - epidemiology
Coronavirus Infections - transmission
Coronaviruses
COVID-19
Disease transmission
Family Health
Female
Genomes
Humans
Infant
Male
Middle Aged
Pandemics
Phylogeny
Pneumonia, Viral - epidemiology
Pneumonia, Viral - transmission
Quarantine
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
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Summary:Abstract Data concerning the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic and paucisymptomatic patients are lacking. We report a 3-family cluster of infections involving asymptomatic and paucisymptomatic transmission. Eight of 15 (53%) members from 3 families were confirmed with SARS-CoV-2 infection. Of 8 patients, 3 were asymptomatic and 1 was paucisymptomatic. An asymptomatic mother transmitted the virus to her son, and a paucisymptomatic father transmitted the virus to his 3-month-old daughter. SARS-CoV-2 was detected in the environment of 1 household. The complete genomes of SARS-CoV-2 from the patients were > 99.9% identical and were clustered with other SARS-CoV-2 sequences reported from China and other countries. We report a unique 3-family cluster of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The transmission of SARS-CoV-2 by individuals with asymptomatic or paucisymptomatic infections likely occurred. SARS-CoV-2 was detected in contaminated environments of 1 household.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa206