HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures

Abstract Motivation HotSpot3D is a widely used software for identifying mutation hotspots on the 3D structures of proteins. To further assist users, we developed a new HotSpot3D web server to make this software more versatile, convenient and interactive. Results The HotSpot3D web server performs dat...

Full description

Saved in:
Bibliographic Details
Published in:Bioinformatics 2020-06, Vol.36 (12), p.3944-3946
Main Authors: Chen, Shanyu, He, Xiaoyu, Li, Ruilin, Duan, Xiaohong, Niu, Beifang
Format: Article
Language:English
Subjects:
Computers
Databases, Factual
Internet
Mutation
Proteins - genetics
Software
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Motivation HotSpot3D is a widely used software for identifying mutation hotspots on the 3D structures of proteins. To further assist users, we developed a new HotSpot3D web server to make this software more versatile, convenient and interactive. Results The HotSpot3D web server performs data pre-processing, clustering, visualization and log-viewing on one stop. Users can interactively explore each cluster and easily re-visualize the mutational clusters within browsers. We also provide a database that allows users to search and visualize proximal mutations from 33 cancers in the Cancer Genome Atlas. Availability and implementation http://niulab.scgrid.cn/HotSpot3D/. Supplementary information Supplementary data are available at Bioinformatics online.
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btaa258