Loading…
Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents
Objectives This basic mechanistic study examined the changes in brain activation and resting‐state connectivity after 8 weeks of CBT in youth with migraine. Background Cognitive behavioral therapy (CBT) is a psychological intervention that is effective in reducing pain in migraine patients. However,...
Saved in:
| Published in: | Headache 2020-06, Vol.60 (6), p.1165-1182 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c3574-8b176bc46aa7f80d86c32bc61a0783e71dad09aebef9850978551aff26c4603b3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c3574-8b176bc46aa7f80d86c32bc61a0783e71dad09aebef9850978551aff26c4603b3 |
| container_end_page | 1182 |
| container_issue | 6 |
| container_start_page | 1165 |
| container_title | Headache |
| container_volume | 60 |
| creator | Nahman‐Averbuch, Hadas Schneider, Victor J. Chamberlin, Leigh Ann Kroon Van Diest, Ashley M. Peugh, James L. Lee, Gregory R. Radhakrishnan, Rupa Hershey, Andrew D. King, Christopher D. Coghill, Robert C. Powers, Scott W. |
| description | Objectives
This basic mechanistic study examined the changes in brain activation and resting‐state connectivity after 8 weeks of CBT in youth with migraine.
Background
Cognitive behavioral therapy (CBT) is a psychological intervention that is effective in reducing pain in migraine patients. However, the neural mechanisms underlying CBT in adolescents with migraine are not yet known.
Methods
Eighteen adolescents with migraine (15 females, age 15.1 ± 2.1 years [mean ± SD]) completed 8 weekly CBT sessions. Before the first and after the final CBT session, participants underwent structural and resting‐state blood‐oxygen‐level‐dependent contrast MRI scans. Arterial spin labeling was also used to examine brain activation during the resting state. For connectivity analyses, the right and left amygdala were chosen as seed regions. Relationships of the time courses within these seeds with voxels across the whole brain were evaluated.
Results
Headache frequency decreased from 15 ± 7.4 headaches per month before CBT to 10 ± 7.4 after CBT (P |
| doi_str_mv | 10.1111/head.13814 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2394258802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2394258802</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3574-8b176bc46aa7f80d86c32bc61a0783e71dad09aebef9850978551aff26c4603b3</originalsourceid><addsrcrecordid>eNp9kc1OxCAUhYnR6Di68QEMiRtjUgXaAl3W8TcZ40bXhLa3DqYDI7SaeXupoy5cyE0guXzncMNB6IiScxrXxQJ0c05TSbMtNKE540nGKdlGE0KoSKTI5B7aD-GVEJLxgu-ivZTFkkJMkCm7HrzujbMBG4svvY77zWDrsYXLNt7imXuxpjfvgC9hod-N87rDT4uoW61x6zx-MC-jDkaH2cJ0jQeLtW1w2bgOQg22Dwdop9VdgMPvc4qeb66fZnfJ_PH2flbOkzrNRZbIigpe1RnXWrSSNJLXKatqTjURMgVBG92QQkMFbSFzUgiZ51S3LeNRQ9IqnaLTje_Ku7cBQq-WJk7QddqCG4JiaZGxXErCInryB311g7dxOsWy8TmWMxmpsw1VexeCh1atvFlqv1aUqDEANQagvgKI8PG35VAtoflFf348AnQDfJgO1v9Yqbvr8mpj-gliJY_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2407832528</pqid></control><display><type>article</type><title>Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Nahman‐Averbuch, Hadas ; Schneider, Victor J. ; Chamberlin, Leigh Ann ; Kroon Van Diest, Ashley M. ; Peugh, James L. ; Lee, Gregory R. ; Radhakrishnan, Rupa ; Hershey, Andrew D. ; King, Christopher D. ; Coghill, Robert C. ; Powers, Scott W.</creator><creatorcontrib>Nahman‐Averbuch, Hadas ; Schneider, Victor J. ; Chamberlin, Leigh Ann ; Kroon Van Diest, Ashley M. ; Peugh, James L. ; Lee, Gregory R. ; Radhakrishnan, Rupa ; Hershey, Andrew D. ; King, Christopher D. ; Coghill, Robert C. ; Powers, Scott W.</creatorcontrib><description>Objectives
This basic mechanistic study examined the changes in brain activation and resting‐state connectivity after 8 weeks of CBT in youth with migraine.
Background
Cognitive behavioral therapy (CBT) is a psychological intervention that is effective in reducing pain in migraine patients. However, the neural mechanisms underlying CBT in adolescents with migraine are not yet known.
Methods
Eighteen adolescents with migraine (15 females, age 15.1 ± 2.1 years [mean ± SD]) completed 8 weekly CBT sessions. Before the first and after the final CBT session, participants underwent structural and resting‐state blood‐oxygen‐level‐dependent contrast MRI scans. Arterial spin labeling was also used to examine brain activation during the resting state. For connectivity analyses, the right and left amygdala were chosen as seed regions. Relationships of the time courses within these seeds with voxels across the whole brain were evaluated.
Results
Headache frequency decreased from 15 ± 7.4 headaches per month before CBT to 10 ± 7.4 after CBT (P < .001). After CBT, greater brain activations in frontal regions involved in cognitive regulation of pain were found. In addition, after CBT increased connectivity between the amygdala and frontal regions was observed. Associations between brain activation and amygdalar connectivity with a reduction in headache frequency were also observed.
Conclusions
Alterations in brain function and amygdalar connectivity with areas involved in nociceptive processing, cognitive function, and emotional regulation may underlie the ability of CBT to aid in the prevention of headaches in migraine patients.</description><identifier>ISSN: 0017-8748</identifier><identifier>EISSN: 1526-4610</identifier><identifier>DOI: 10.1111/head.13814</identifier><identifier>PMID: 32323877</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Adolescents ; Amygdala ; Amygdala - diagnostic imaging ; Amygdala - physiopathology ; Behavior modification ; Brain ; Child ; Children ; Cognitive ability ; Cognitive Behavioral Therapy ; Connectome ; Follow-Up Studies ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - physiopathology ; functional magnetic resonance imaging ; Headache ; Humans ; Information processing ; Magnetic Resonance Imaging ; Male ; Migraine ; Migraine Disorders - diagnostic imaging ; Migraine Disorders - physiopathology ; Migraine Disorders - therapy ; Neural networks ; Pain ; Pain perception ; Spin labeling ; Teenagers ; Treatment Outcome ; Youth</subject><ispartof>Headache, 2020-06, Vol.60 (6), p.1165-1182</ispartof><rights>2020 American Headache Society</rights><rights>2020 American Headache Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-8b176bc46aa7f80d86c32bc61a0783e71dad09aebef9850978551aff26c4603b3</citedby><cites>FETCH-LOGICAL-c3574-8b176bc46aa7f80d86c32bc61a0783e71dad09aebef9850978551aff26c4603b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32323877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nahman‐Averbuch, Hadas</creatorcontrib><creatorcontrib>Schneider, Victor J.</creatorcontrib><creatorcontrib>Chamberlin, Leigh Ann</creatorcontrib><creatorcontrib>Kroon Van Diest, Ashley M.</creatorcontrib><creatorcontrib>Peugh, James L.</creatorcontrib><creatorcontrib>Lee, Gregory R.</creatorcontrib><creatorcontrib>Radhakrishnan, Rupa</creatorcontrib><creatorcontrib>Hershey, Andrew D.</creatorcontrib><creatorcontrib>King, Christopher D.</creatorcontrib><creatorcontrib>Coghill, Robert C.</creatorcontrib><creatorcontrib>Powers, Scott W.</creatorcontrib><title>Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents</title><title>Headache</title><addtitle>Headache</addtitle><description>Objectives
This basic mechanistic study examined the changes in brain activation and resting‐state connectivity after 8 weeks of CBT in youth with migraine.
Background
Cognitive behavioral therapy (CBT) is a psychological intervention that is effective in reducing pain in migraine patients. However, the neural mechanisms underlying CBT in adolescents with migraine are not yet known.
Methods
Eighteen adolescents with migraine (15 females, age 15.1 ± 2.1 years [mean ± SD]) completed 8 weekly CBT sessions. Before the first and after the final CBT session, participants underwent structural and resting‐state blood‐oxygen‐level‐dependent contrast MRI scans. Arterial spin labeling was also used to examine brain activation during the resting state. For connectivity analyses, the right and left amygdala were chosen as seed regions. Relationships of the time courses within these seeds with voxels across the whole brain were evaluated.
Results
Headache frequency decreased from 15 ± 7.4 headaches per month before CBT to 10 ± 7.4 after CBT (P < .001). After CBT, greater brain activations in frontal regions involved in cognitive regulation of pain were found. In addition, after CBT increased connectivity between the amygdala and frontal regions was observed. Associations between brain activation and amygdalar connectivity with a reduction in headache frequency were also observed.
Conclusions
Alterations in brain function and amygdalar connectivity with areas involved in nociceptive processing, cognitive function, and emotional regulation may underlie the ability of CBT to aid in the prevention of headaches in migraine patients.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Amygdala</subject><subject>Amygdala - diagnostic imaging</subject><subject>Amygdala - physiopathology</subject><subject>Behavior modification</subject><subject>Brain</subject><subject>Child</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Cognitive Behavioral Therapy</subject><subject>Connectome</subject><subject>Follow-Up Studies</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Frontal Lobe - physiopathology</subject><subject>functional magnetic resonance imaging</subject><subject>Headache</subject><subject>Humans</subject><subject>Information processing</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Migraine</subject><subject>Migraine Disorders - diagnostic imaging</subject><subject>Migraine Disorders - physiopathology</subject><subject>Migraine Disorders - therapy</subject><subject>Neural networks</subject><subject>Pain</subject><subject>Pain perception</subject><subject>Spin labeling</subject><subject>Teenagers</subject><subject>Treatment Outcome</subject><subject>Youth</subject><issn>0017-8748</issn><issn>1526-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc1OxCAUhYnR6Di68QEMiRtjUgXaAl3W8TcZ40bXhLa3DqYDI7SaeXupoy5cyE0guXzncMNB6IiScxrXxQJ0c05TSbMtNKE540nGKdlGE0KoSKTI5B7aD-GVEJLxgu-ivZTFkkJMkCm7HrzujbMBG4svvY77zWDrsYXLNt7imXuxpjfvgC9hod-N87rDT4uoW61x6zx-MC-jDkaH2cJ0jQeLtW1w2bgOQg22Dwdop9VdgMPvc4qeb66fZnfJ_PH2flbOkzrNRZbIigpe1RnXWrSSNJLXKatqTjURMgVBG92QQkMFbSFzUgiZ51S3LeNRQ9IqnaLTje_Ku7cBQq-WJk7QddqCG4JiaZGxXErCInryB311g7dxOsWy8TmWMxmpsw1VexeCh1atvFlqv1aUqDEANQagvgKI8PG35VAtoflFf348AnQDfJgO1v9Yqbvr8mpj-gliJY_Q</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Nahman‐Averbuch, Hadas</creator><creator>Schneider, Victor J.</creator><creator>Chamberlin, Leigh Ann</creator><creator>Kroon Van Diest, Ashley M.</creator><creator>Peugh, James L.</creator><creator>Lee, Gregory R.</creator><creator>Radhakrishnan, Rupa</creator><creator>Hershey, Andrew D.</creator><creator>King, Christopher D.</creator><creator>Coghill, Robert C.</creator><creator>Powers, Scott W.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202006</creationdate><title>Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents</title><author>Nahman‐Averbuch, Hadas ; Schneider, Victor J. ; Chamberlin, Leigh Ann ; Kroon Van Diest, Ashley M. ; Peugh, James L. ; Lee, Gregory R. ; Radhakrishnan, Rupa ; Hershey, Andrew D. ; King, Christopher D. ; Coghill, Robert C. ; Powers, Scott W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-8b176bc46aa7f80d86c32bc61a0783e71dad09aebef9850978551aff26c4603b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Amygdala</topic><topic>Amygdala - diagnostic imaging</topic><topic>Amygdala - physiopathology</topic><topic>Behavior modification</topic><topic>Brain</topic><topic>Child</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Cognitive Behavioral Therapy</topic><topic>Connectome</topic><topic>Follow-Up Studies</topic><topic>Frontal Lobe - diagnostic imaging</topic><topic>Frontal Lobe - physiopathology</topic><topic>functional magnetic resonance imaging</topic><topic>Headache</topic><topic>Humans</topic><topic>Information processing</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Migraine</topic><topic>Migraine Disorders - diagnostic imaging</topic><topic>Migraine Disorders - physiopathology</topic><topic>Migraine Disorders - therapy</topic><topic>Neural networks</topic><topic>Pain</topic><topic>Pain perception</topic><topic>Spin labeling</topic><topic>Teenagers</topic><topic>Treatment Outcome</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nahman‐Averbuch, Hadas</creatorcontrib><creatorcontrib>Schneider, Victor J.</creatorcontrib><creatorcontrib>Chamberlin, Leigh Ann</creatorcontrib><creatorcontrib>Kroon Van Diest, Ashley M.</creatorcontrib><creatorcontrib>Peugh, James L.</creatorcontrib><creatorcontrib>Lee, Gregory R.</creatorcontrib><creatorcontrib>Radhakrishnan, Rupa</creatorcontrib><creatorcontrib>Hershey, Andrew D.</creatorcontrib><creatorcontrib>King, Christopher D.</creatorcontrib><creatorcontrib>Coghill, Robert C.</creatorcontrib><creatorcontrib>Powers, Scott W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Headache</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nahman‐Averbuch, Hadas</au><au>Schneider, Victor J.</au><au>Chamberlin, Leigh Ann</au><au>Kroon Van Diest, Ashley M.</au><au>Peugh, James L.</au><au>Lee, Gregory R.</au><au>Radhakrishnan, Rupa</au><au>Hershey, Andrew D.</au><au>King, Christopher D.</au><au>Coghill, Robert C.</au><au>Powers, Scott W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents</atitle><jtitle>Headache</jtitle><addtitle>Headache</addtitle><date>2020-06</date><risdate>2020</risdate><volume>60</volume><issue>6</issue><spage>1165</spage><epage>1182</epage><pages>1165-1182</pages><issn>0017-8748</issn><eissn>1526-4610</eissn><abstract>Objectives
This basic mechanistic study examined the changes in brain activation and resting‐state connectivity after 8 weeks of CBT in youth with migraine.
Background
Cognitive behavioral therapy (CBT) is a psychological intervention that is effective in reducing pain in migraine patients. However, the neural mechanisms underlying CBT in adolescents with migraine are not yet known.
Methods
Eighteen adolescents with migraine (15 females, age 15.1 ± 2.1 years [mean ± SD]) completed 8 weekly CBT sessions. Before the first and after the final CBT session, participants underwent structural and resting‐state blood‐oxygen‐level‐dependent contrast MRI scans. Arterial spin labeling was also used to examine brain activation during the resting state. For connectivity analyses, the right and left amygdala were chosen as seed regions. Relationships of the time courses within these seeds with voxels across the whole brain were evaluated.
Results
Headache frequency decreased from 15 ± 7.4 headaches per month before CBT to 10 ± 7.4 after CBT (P < .001). After CBT, greater brain activations in frontal regions involved in cognitive regulation of pain were found. In addition, after CBT increased connectivity between the amygdala and frontal regions was observed. Associations between brain activation and amygdalar connectivity with a reduction in headache frequency were also observed.
Conclusions
Alterations in brain function and amygdalar connectivity with areas involved in nociceptive processing, cognitive function, and emotional regulation may underlie the ability of CBT to aid in the prevention of headaches in migraine patients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32323877</pmid><doi>10.1111/head.13814</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0017-8748 |
| ispartof | Headache, 2020-06, Vol.60 (6), p.1165-1182 |
| issn | 0017-8748 1526-4610 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2394258802 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Adolescents Amygdala Amygdala - diagnostic imaging Amygdala - physiopathology Behavior modification Brain Child Children Cognitive ability Cognitive Behavioral Therapy Connectome Follow-Up Studies Frontal Lobe - diagnostic imaging Frontal Lobe - physiopathology functional magnetic resonance imaging Headache Humans Information processing Magnetic Resonance Imaging Male Migraine Migraine Disorders - diagnostic imaging Migraine Disorders - physiopathology Migraine Disorders - therapy Neural networks Pain Pain perception Spin labeling Teenagers Treatment Outcome Youth |
| title | Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T20%3A51%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alterations%20in%20Brain%20Function%20After%20Cognitive%20Behavioral%20Therapy%20for%20Migraine%20in%20Children%20and%20Adolescents&rft.jtitle=Headache&rft.au=Nahman%E2%80%90Averbuch,%20Hadas&rft.date=2020-06&rft.volume=60&rft.issue=6&rft.spage=1165&rft.epage=1182&rft.pages=1165-1182&rft.issn=0017-8748&rft.eissn=1526-4610&rft_id=info:doi/10.1111/head.13814&rft_dat=%3Cproquest_cross%3E2394258802%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3574-8b176bc46aa7f80d86c32bc61a0783e71dad09aebef9850978551aff26c4603b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2407832528&rft_id=info:pmid/32323877&rfr_iscdi=true |