A Double‐Layered Microneedle Platform Fabricated through Frozen Spray‐Coating

This work reports a frozen spray‐coating method for the fabrication of double‐layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)‐derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC‐Dextran, Insulin) can be homogeneously...

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Bibliographic Details
Published in:Advanced healthcare materials 2020-05, Vol.9 (10), p.e2000147-n/a
Main Authors: Ning, Xiaoyu, Wiraja, Christian, Lio, Daniel Chin Shiuan, Xu, Chenjie
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Biomarkers
Blood circulation
Blood glucose
Coating
Coatings
Dextran
double‐layered microneedles
Drug Delivery Systems
frozen spray‐coating
Glucose
Hyaluronic acid
Hydrophobicity
Insulin
interstitial skin fluid extraction
Mechanical properties
Mice
Microinjections
Needles
Skin
transdermal drug delivery
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Summary:This work reports a frozen spray‐coating method for the fabrication of double‐layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)‐derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC‐Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double‐layered MNs can execute multiple roles. It is demonstrated that insulin‐coated MeHA double‐layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose). This paper describes a simple and yet versatile strategy to fabricate double‐layered microneedles. With the proposed strategy, various molecules with different physicochemical properties can be coated on microneedles without the loss of their biological and chemical activities, creating potentials for a wide range of applications including controlled drug delivery and biosensing.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202000147