Immune profiles provide insights into respiratory syncytial virus disease severity in young children

Respiratory syncytial virus (RSV) is associated with major morbidity in infants, although most cases result in mild disease. The pathogenesis of the disease is incompletely understood, especially the determining factors of disease severity. A better characterization of these factors may help with de...

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Bibliographic Details
Published in:Science translational medicine 2020-04, Vol.12 (540), p.1
Main Authors: Heinonen, Santtu, Velazquez, Victoria M, Ye, Fang, Mertz, Sara, Acero-Bedoya, Santiago, Smith, Bennett, Bunsow, Eleonora, Garcia-Mauriño, Cristina, Oliva, Silvia, Cohen, Daniel M, Moore-Clingenpeel, Melissa, Peeples, Mark E, Ramilo, Octavio, Mejias, Asuncion
Format: Article
Language:English
Subjects:
Antiviral agents
Children
Clinical trials
Histocompatibility antigen HLA
Immune response
Infants
Innate immunity
Interferon
Monocytes
Morbidity
Phenotypes
Respiratory syncytial virus
Transcription
Vaccines
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Summary:Respiratory syncytial virus (RSV) is associated with major morbidity in infants, although most cases result in mild disease. The pathogenesis of the disease is incompletely understood, especially the determining factors of disease severity. A better characterization of these factors may help with development of RSV vaccines and antivirals. Hence, identification of a "safe and protective" immunoprofile induced by natural RSV infection could be used as a as a surrogate of ideal vaccine-elicited responses in future clinical trials. In this study, we integrated blood transcriptional and cell immune profiling, RSV loads, and clinical data to identify factors associated with a mild disease phenotype in a cohort of 190 children
ISSN:1946-6234
1946-6242
1946-3242
DOI:10.1126/scitranslmed.aaw0268