Estimating a normal reference range for serum B‐cell maturation antigen levels for multiple myeloma patients

Summary The serum B‐cell maturation antigen (sBCMA) has been identified as a novel serum biomarker for patients with multiple myeloma. However, no study has yet established a reference range for sBCMA levels. Its levels were determined in 196 healthy subjects and showed a right‐tailed distribution w...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 2021-03, Vol.192 (6), p.1064-1067
Main Authors: Jew, Scott, Bujarski, Sean, Soof, Camilia, Chen, Haiming, Safaie, Tahmineh, Li, Mingjie, Sanchez, Eric, Wang, Cathy, Emamy‐Sadr, Marsiye, Swift, Regina, Rahbari, Ashkon, Patil, Saurabh, Souther, Eric, Spektor, Tanya M., Berenson, James R.
Format: Article
Language:English
Subjects:
Antigens
Hematology
Multiple myeloma
reference range
serum BCMA
Standard deviation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The serum B‐cell maturation antigen (sBCMA) has been identified as a novel serum biomarker for patients with multiple myeloma. However, no study has yet established a reference range for sBCMA levels. Its levels were determined in 196 healthy subjects and showed a right‐tailed distribution with a median value of 37·51 ng/ml with a standard deviation of 22·54 ng/ml (range 18·78–180·39 ng/ml). Partitioning of subgroup reference ranges was considered but determined to be irrelevant. A non‐parametric method using the median ± 2 standard deviations suggests using a universal reference interval of
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.16673