Response of the Hemostatic System to Acute Vital Stress in Rats

We studied the effect of acute vital stress on the parameters of the hemostasis system in young and old Wistar rats. The psychotraumatic effect was simulated as a situation of emotional stress at the sight of a predator (Indian python) catching and eating a conspecific. In young rats, acute vital st...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-04, Vol.168 (6), p.724-726
Main Authors: Bondarchuk, Yu. A., Alekseeva, O. V., Shakhmatov, I. I., Krinitsina, I. N.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Antithrombin III - metabolism
Biomedical and Life Sciences
Biomedicine
Blood Coagulation Tests
Blood Platelets - cytology
Blood Platelets - physiology
Boidae - physiology
Cell Biology
Fibrin
Fibrinogen - metabolism
Hemostasis
Internal Medicine
Laboratory Medicine
Male
Neurophysiology
Pathology
Platelet Aggregation - physiology
Platelet Count
Predatory Behavior - physiology
Pythons
Rats
Rats, Wistar
Stress (Psychology)
Stress, Psychological - blood
Stress, Psychological - physiopathology
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Summary:We studied the effect of acute vital stress on the parameters of the hemostasis system in young and old Wistar rats. The psychotraumatic effect was simulated as a situation of emotional stress at the sight of a predator (Indian python) catching and eating a conspecific. In young rats, acute vital stress was followed by inhibition of platelet aggregation, hypercoagulation by the external pathway and final stages of plasma hemostasis, and a decrease in fibrinogen and antithrombin III levels against the background of fibrinolysis activation. In old animals, increased platelet count with reduced aggregation capacity, hypocoagulation by the internal pathway of the plasma hemostasis activation, signs of thrombinemia (a 2-fold increase in soluble fibrin-monomer complexes), an increase in antithrombin III, and inhibition of the fibrinolytic system were observed. Age-related changes in the hemostasis parameters in rats were determined before and after stress exposure.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04788-8