pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy

To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy. The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which thei...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2020-05, Vol.15 (11), p.1097-1112
Main Authors: Zhang, Guiyang, Gou, Huilin, Liu, Yanfeng, Xi, Kai, Jiang, Dechen, Jia, Xudong
Format: Article
Language:English
Subjects:
Acids
Biocompatibility
Cancer therapies
Cell Line, Tumor
Chitosan
Combination therapy
Ethanol
Ferric Compounds
Heat
Hydrogen-Ion Concentration
Iron
iron oxide
Lasers
low-power laser
Nanoparticles
PDT/PTT
PEG
Photochemotherapy
Photosensitizing Agents - therapeutic use
Phototherapy
self-assembly
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Summary:To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy. The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated. The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues. The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2020-0022