Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities

Three new quassinoids, javanicinols A and B ( 1 and 2 ) and 4-keto-(16 S )-methoxyjavanicin B ( 3 ), together with three known quassinoids ( 4–6 ) were isolated from the chloroform-soluble fraction of the methanol extract of the Picrasma javanica wood. The structures of 1–3 were determined by spectr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural medicines 2020-06, Vol.74 (3), p.571-578
Main Authors: Prema, Wong, Chin Piow, Kodama, Takeshi, Nugroho, Alfarius Eko, El-Desoky, Ahmad H., Awouafack, Maurice Ducret, Win, Yi Yi, Ngwe, Hla, Abe, Ikuro, Morita, Hiroshi, Morita, Hiroyuki
Format: Article
Language:English
Subjects:
Antiviral agents
Biological products
Biomedical and Life Sciences
Biomedicine
Chloroform
Complementary & Alternative Medicine
HIV
Human immunodeficiency virus
Medicinal Chemistry
NMR
Nuclear magnetic resonance
Original Paper
Pharmacology/Toxicology
Pharmacy
Picrasma
Plant Sciences
Quassinoids
Vpr protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three new quassinoids, javanicinols A and B ( 1 and 2 ) and 4-keto-(16 S )-methoxyjavanicin B ( 3 ), together with three known quassinoids ( 4–6 ) were isolated from the chloroform-soluble fraction of the methanol extract of the Picrasma javanica wood. The structures of 1–3 were determined by spectroscopic analyses, including 1D and 2D NMR, HRESIMS, and CD. The anti-HIV-1 viral protein R (Vpr) assay revealed that 1 and 2 exhibited potent anti-Vpr activities at 1.25 μM. Furthermore, the assay also revealed the potent anti-Vpr activities of (16 R )-methoxyjavanicin B ( 7 ) and (16 S )-methoxyjavanicin B ( 8 ), which were previously isolated from the Picrasma javanica wood.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-020-01411-y