Dopamine‐Modified Zero‐Valent Iron Nanoparticles for Dual‐Modality Photothermal and Photodynamic Breast Cancer Therapy

Phototherapy has the advantages of minimal invasion, few side effects, and improved accuracy for cancer therapy. The application of a polydopamine (PDA)‐modified nano zero‐valent iron (nZVI@PDA) as a new synergistic agent in combination with photodynamic/photothermal (PD/PT) therapy to kill cancer c...

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Bibliographic Details
Published in:ChemMedChem 2020-09, Vol.15 (17), p.1645-1651
Main Authors: Yu, Hsin Her, Lin, Chia‐Hua, Chen, Yi‐Chun, Chen, Hung‐Hsiang, Lin, Yu‐Jing, Lin, Kun‐Yi Andrew
Format: Article
Language:English
Subjects:
Apoptosis
Biocompatibility
Breast cancer
Cancer
Cancer therapies
Dopamine
I.R. radiation
Iron
Irradiation
nano zero-valent iron
Nanoparticles
Nanotechnology devices
near-infrared
photodynamic therapy
Photons
Phototherapy
Photothermal conversion
photothermal therapy
Radiation damage
Side effects
Therapy
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Summary:Phototherapy has the advantages of minimal invasion, few side effects, and improved accuracy for cancer therapy. The application of a polydopamine (PDA)‐modified nano zero‐valent iron (nZVI@PDA) as a new synergistic agent in combination with photodynamic/photothermal (PD/PT) therapy to kill cancer cells is discussed here. The nZVI@PDA offered high light‐to‐heat conversion and ROS generation efficiency under near‐infrared (NIR) irradiation (808 nm), thus leading to irreversible damage to nZVI@PDA‐treated MCF‐7 cells at low concentration, without inducing apoptosis in normal cells. Irradiation of nZVI@PDA using an NIR laser converted the energy of the photons to heat and ROS. Our results showed that modification of the PDA on the surface of nZVI can improve the biocompatibility of the nZVI@PDA. This work integrated the PD and PT effects into a single nanodevice to afford a highly efficient cancer treatment. Meanwhile, nZVI@PDA, which combines the advantages of PDA and nZVI, displayed excellent biocompatibility and tumoricidal ability, thus suggesting its huge potential for future clinical research in cancer therapy. Too hot to handle: Polydopamine‐modified nano zero‐valent iron (nZVI@PDA) can deliver heat and ROS to effectively inhibit cancer cell growth through apoptosis. It exhibits high photothermal conversion and ROS production efficiency, good recyclability and long‐term stability. Therefore, nZVI@PDA has a great potential to develop as a highly efficient, safe therapeutic agent for combinatorial photothermal/photodynamic therapy for breast cancer.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202000192