To D or not to D: vitamin D in hematopoietic cell transplantation

Vitamin D plays an essential role in bone health, immune tolerance, and immune modulation. Autologous and allogeneic hematopoietic cell transplantation (HCT) recipients are at increased risk of vitamin D deficiency, which may increase risks of bone loss and fracture, graft-versus-host disease (GVHD)...

Full description

Saved in:
Bibliographic Details
Published in:Bone marrow transplantation (Basingstoke) 2020-11, Vol.55 (11), p.2060-2070
Main Authors: Hong, Sanghee, Ferraro, Christina S., Hamilton, Betty K., Majhail, Navneet S.
Format: Article
Language:English
Subjects:
692/499
692/700/459
Adult
Alfacalcidol
Autografts
Biomedical materials
Bone densitometry
Bone grafts
Bone loss
Calcifediol
Calciferol
Cell Biology
Denosumab
Densitometers
Densitometry
Disodium pamidronate
Graft vs Host Disease - etiology
Graft vs Host Disease - prevention & control
Graft-versus-host reaction
Health aspects
Health risks
Hematology
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Immunological tolerance
Immunomodulation
Immunomodulators
Internal Medicine
Medicine
Medicine & Public Health
Mortality
Osteoporosis
Public Health
Review Article
Risk
Stem cell transplantation
Stem Cells
Supplements
Transplantation
Transplantation, Homologous
Vitamin D
Vitamin D Deficiency
Vitamin deficiency
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vitamin D plays an essential role in bone health, immune tolerance, and immune modulation. Autologous and allogeneic hematopoietic cell transplantation (HCT) recipients are at increased risk of vitamin D deficiency, which may increase risks of bone loss and fracture, graft-versus-host disease (GVHD), and relapse, and can delay hematologic and immune recovery following HCT. Growing evidence indicates that vitamin D may have a role as an immunomodulator, and supplementation during HCT may decrease the risk of GVHD, infection, relapse, and mortality. In this paper, we review the role of vitamin D and its association with HCT outcomes and discuss prevention and treatment of vitamin D deficiency after HCT in adult recipients. We review the role of monitoring of vitamin D levels pre- and post-HCT and its supplementation in appropriate patients. We also review the use of bone densitometry prior to HCT and in long-term follow-up and the treatment of osteoporosis in this high-risk population.
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-020-0904-7