Preoperative Prognostic Nutritional Index is a Significant Predictor of Survival in Esophageal Squamous Cell Carcinoma Patients

Background: Preoperative assessment of patients is meaningful to predict survival in patients with malignant tumors. The prognostic nutritional index (PNI) is one of the most significant factors related to the prognosis in various types of cancer; however, its role in esophageal cancer is still inco...

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Bibliographic Details
Published in:Nutrition and cancer 2021, Vol.73 (2), p.215-220
Main Authors: Xiao, Fan-kai, Wang, Lin, Zhang, Wen cai, Wang, Li-dong, Zhao, Luo-sha
Format: Article
Language:English
Subjects:
Cancer
Cell number
Cell survival
Esophageal cancer
Esophagus
Lymphocytes
Medical prognosis
Multivariate analysis
Nutrition assessment
Serum albumin
Squamous cell carcinoma
Surgery
Survival
Tumors
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Summary:Background: Preoperative assessment of patients is meaningful to predict survival in patients with malignant tumors. The prognostic nutritional index (PNI) is one of the most significant factors related to the prognosis in various types of cancer; however, its role in esophageal cancer is still inconclusive. The aim of this study was to identify the prognostic value of PNI in predicting overall survival (OS) in esophageal squamous cell carcinoma (ESCC). Methods: This retrospective study included 4146 ESCC patients, 3812 who underwent esophagectomy for ESCC. Other 334 had no surgery. The Preoperative PNI was measured before any therapies and calculated as 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm3). We classified the patients into three categories according to the PNI, >50, 45-50, and
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2020.1757129