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Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta‐analysis

Background Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited. Objectives To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trop...

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Published in:BJOG : an international journal of obstetrics and gynaecology 2020-11, Vol.127 (12), p.1450-1457
Main Authors: Zilberman Sharon, N, Maymon, R, Melcer, Y, Jauniaux, E
Format: Article
Language:English
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Summary:Background Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited. Objectives To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trophoblastic neoplasia (GTN) in twin pregnancies including a CHM. Search strategy PubMed, MEDLINE and EMBASE and the grey literature were searched for articles published between May 1980 and May 2019 using a protocol designed a priori and registered on PROSPERO (CRD42018112524). Selection criteria Observational cohort studies of four or more cases confirmed by histopathology and providing data on pregnancy outcomes and GTN. Data collection and analysis Two reviewers independently reviewed s and full‐text articles. The quality of the studies was assessed with the Newcastle‐Ottawa scale and a meta‐analysis was performed. Main results Of the 344 s identified, 14 studies (244 cases) met the eligibility criteria. The incidence of maternal complication in ongoing pregnancies was 80.8% and included vaginal bleeding, hyperthyroidism and pre‐eclampsia. There were overall 91 (50%) live births in ongoing pregnancies and 83 (34%) of the total cases were subsequently diagnosed with GTN. Substantial and significant (P 
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.16283