Innate Lymphocyte Mechanisms in Skin Diseases

Innate lymphocyte populations are emerging as key effectors in tissue homeostasis, microbial defense, and inflammatory skin disease. The cells are evolutionarily ancient and carry conserved principles of function, which can be achieved through shared or unique specific mechanisms. Recent technologic...

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Bibliographic Details
Published in:Annual review of immunology 2020-04, Vol.38 (1), p.171-202
Main Authors: Chen, Yi-Ling, Hardman, Clare S, Yadava, Koshika, Ogg, Graham
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Homeostasis
Host-Pathogen Interactions - immunology
Humans
Immunity, Innate
innate
Lymphocyte Subsets - immunology
Lymphocyte Subsets - metabolism
lymphocytes
Microbiota - immunology
Signal Transduction
skin
Skin Diseases - etiology
Skin Diseases - metabolism
Skin Diseases - pathology
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Summary:Innate lymphocyte populations are emerging as key effectors in tissue homeostasis, microbial defense, and inflammatory skin disease. The cells are evolutionarily ancient and carry conserved principles of function, which can be achieved through shared or unique specific mechanisms. Recent technological and treatment advances have provided insight into heterogeneity within and between individuals and species. Similar pathways can extend through to adaptive lymphocytes, which softens the margins with innate lymphocyte populations and allows investigation of nonredundant pathways of immunity and inflammation that might be amenable to therapeutic intervention. Here, we review advances in understanding of innate lymphocyte biology with a focus on skin disease and the roles of commensal and pathogen responses and tissue homeostasis.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev-immunol-082919-093554