Personalized Approach to Determination of Histidine-Rich Glycoprotein and E-Cadherin in Supernatants of Immunocompetent Blood Cells and Breast Biopsy Specimens in Breast Malignant and Non-Malignant Disease

The material of patients with invasive carcinoma of no special type (ICNT) and nonmalignant diseases (ND) of the mammary gland was studied. When comparing the concentrations of histidine-rich glycoprotein (HRG) and E-cadherin (CDH1), statistically significant differences between ICNT and ND by HRG i...

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Published in:Doklady. Biochemistry and biophysics 2020, Vol.490 (1), p.1-4
Main Authors: Autenshlyus, A. I., Bernado, A. V., Studenikina, A. A., Proskura, A. V., Davletova, K. I., Zhurakovskiy, I. P., Arkhipov, S. A., Varaksin, N. A., Sidorov, S. V., Lyakhovich, V. V.
Format: Article
Language:English
Subjects:
Antigens, CD - metabolism
Biochemistry
Biological and Medical Physics
Biomarkers, Tumor - metabolism
Biomedical and Life Sciences
Biophysics
Biopsy
Blood cells
Breast
Breast - metabolism
Breast cancer
Breast Neoplasms - metabolism
Cadherins - metabolism
E-cadherin
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Glycoproteins
Histidine
Humans
Immunocompetence
Immunohistochemistry
Invasiveness
Life Sciences
Mammary gland
Molecular Biology
Polyclonal activators
Proteins - metabolism
Statistical analysis
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Summary:The material of patients with invasive carcinoma of no special type (ICNT) and nonmalignant diseases (ND) of the mammary gland was studied. When comparing the concentrations of histidine-rich glycoprotein (HRG) and E-cadherin (CDH1), statistically significant differences between ICNT and ND by HRG in the supernatant of blood cells and its spontaneous production by biopsies and by CDH1 at its induced production, as well as by influence indices of polyclonal activators on the production of CDH1 were found. When comparing the expression of immunohistochemical markers, no statistically significant differences between ICNT and ND were obtained.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672920010019