Does vegan diet influence umbilical cord vitamin B12, folate, and ferritin levels?

• Published in: Archives of gynecology and obstetrics 2020-06, Vol.301 (6), p.1417-1422
• Main Authors: Avnon, Tomer, Anbar, Ronit, Lavie, Inbar, Ben-Mayor Bashi, Tali, Paz Dubinsky, Efrat, Shaham, Sivan, Yogev, Yariv
• Format: Article
• Language: English
• Subjects: Adult; Diet; Diet, Vegan - methods; Endocrinology; Female; Ferritins - blood; Fetal Blood - chemistry; Folic Acid - blood; Gynecology; Hemoglobin; Human Genetics; Humans; Male; Maternal & child health; Maternal-Fetal Medicine; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Pregnancy; Prospective Studies; Umbilical cord; Veganism; Vegetarianism; Vitamin B; Vitamin B 12 - blood
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-020-05561-y

Purpose To determine the influence of maternal diets on maternal and umbilical cord blood levels of vitamin B12, folic acid, ferritin, and hemoglobin. Methods A prospective observational study on women who maintained the same diet for at least 3 months prior to, and throughout current pregnancy. Women were divided according to their diet. Diet questionnaires were filled in during the 3rd trimester. Blood samples for complete blood counts and levels of ferritin, vitamin B12, folate, and albumin were taken from the women prior to delivery and from the umbilical cord immediately after delivery. Results The 273 enrolled women included 112 omnivores, 37 pescatarians, 64 vegetarians, and 60 vegans. There were no significant differences in the maternal B12 levels between the study groups ( P  = 0.426). Vegans had lower maternal ferritin levels compared to pescatarians (27 ± 17 vs 60 ± 74 ng/ml, respectively, P  = 0.034), but not compared to vegetarians ( P  = 0.597), or omnivores ( P  = 1.000). There were no significant differences in the umbilical cord B12, folate, ferritin, and hemoglobin levels between the study groups. A sub-analysis that compared women who consumed multivitamins, B12 and iron supplements during pregnancy to women who did not, revealed differences in the levels of umbilical-cord B12 (1002 ± 608 vs 442 ± 151 pg/ml, respectively, P  = 0.000) and maternal blood B12 (388 ± 209 vs 219 ± 95 pg/ml, respectively , P  = 0.030) only among vegans, but not among omnivores. Conclusion Vegan diet does not change the umbilical cord levels of B12, folic acid, ferritin, and hemoglobin. Vegans who do not take any vitamin supplementation are at greater risk for B12 deficiency than omnivores.