Targeted imaging of integrins in cancer tissues using photocleavable Ru() polypyridine complexes as mass-tags

Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru( ii ) pol...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-06, Vol.56 (44), p.5941-5944
Main Authors: Han, Jiaying, Sun, Jing, Song, Shanshan, Beljaars, Leonie, Groothuis, Geny M. M, Permentier, Hjalmar, Bischoff, Rainer, Halmos, Gyorgy B, Verhoeven, Cornelia J, Amstalden van Hove, Erika R, Horvatovich, Peter, Casini, Angela
Format: Article
Language:English
Subjects:
Cancer
Head and Neck Neoplasms - metabolism
Humans
Imaging
Integrin alphaVbeta3 - metabolism
Ions
Mass spectrometry
Mass Spectrometry - methods
Peptides, Cyclic - chemistry
Peptides, Cyclic - pharmacology
Pyridines - chemistry
Pyridines - pharmacology
Ruthenium - chemistry
Ruthenium - pharmacology
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Summary:Targeted epitope-based mass spectrometry imaging (MSI) utilizes laser cleavable mass-tags bound to targeting moieties for detecting proteins in tissue sections. Our work constitutes the first proof-of-concept of a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru( ii ) polypyridine complexes as mass-tags for imaging of integrins αvβ3 in human cancer tissues. A novel photocleavable ruthenium-based mass-tag for mass spectrometry imaging of proteins in cancer tissues.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc00774a