Effects of electronic cigarette on platelet and vascular function after four months of use

We examined the effects of electronic cigarette on platelet and vascular function after 4 months of use compared to tobacco smoking. Forty smokers without cardiovascular disease were randomized to smoke either conventional cigarettes or an electronic cigarette (nicotine concentration of 12 mg/ml). A...

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Bibliographic Details
Published in:Food and chemical toxicology 2020-07, Vol.141, p.111389-111389, Article 111389
Main Authors: Ikonomidis, Ignatios, Katogiannis, Konstantinos, Kostelli, Gavriella, Kourea, Kallirhoe, Kyriakou, Elias, Kypraiou, Athina, Tsoumani, Maria, Andreadou, Ioanna, Lambadiari, Vaia, Plotas, Panagiotis, Thymis, Ioannis, Tsantes, Argirios E.
Format: Article
Language:English
Subjects:
Blood Platelets - drug effects
Electronic cigarette
Electronic Nicotine Delivery Systems
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Humans
Light transmission aggregometry
Nicotine - pharmacology
Oxidative stress
PFA-100
Platelets
Pulse wave velocity
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Summary:We examined the effects of electronic cigarette on platelet and vascular function after 4 months of use compared to tobacco smoking. Forty smokers without cardiovascular disease were randomized to smoke either conventional cigarettes or an electronic cigarette (nicotine concentration of 12 mg/ml). At baseline and after four months, we measured a) platelet function by Platelet Function Analyzer PFA-100 and Light Transmission Aggregometry, b) pulse wave velocity, c) plasma malondialdehyde levels as oxidative stress index and d) the exhaled CO level. After 4 months, continuation of conventional cigarette smoking further impaired platelet function compared to vaping as assessed by PFA (mean increase 27.1 vs 11.6 s, p for interaction = 0.048) and by LTA (decline 24.1 vs 9.4%, p for interaction = 0.045). Conversely, compared to smoking, vaping resulted in greater reduction of exhaled CO (6.9 ppm vs 2.6, p for interaction 
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2020.111389