Role of imaging in multiple myeloma

With rapid advancements in the diagnosis and treatment of multiple myeloma (MM), imaging has become instrumental in detection of intramedullary and extramedullary disease, providing prognostic information, and assessing therapeutic efficacy. Whole‐body low dose computed tomography (WBLDCT) has emerg...

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Bibliographic Details
Published in:American journal of hematology 2020-08, Vol.95 (8), p.966-977
Main Authors: Baffour, Francis I., Glazebrook, Katrina N., Kumar, Shaji K., Broski, Stephen M.
Format: Article
Language:English
Subjects:
Bone diseases
Bone imaging
Bone marrow
Computed tomography
Health risk assessment
Hematology
Magnetic resonance imaging
Multiple myeloma
Osteolysis
Positron emission tomography
Tomography
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Summary:With rapid advancements in the diagnosis and treatment of multiple myeloma (MM), imaging has become instrumental in detection of intramedullary and extramedullary disease, providing prognostic information, and assessing therapeutic efficacy. Whole‐body low dose computed tomography (WBLDCT) has emerged as the study of choice to detect osteolytic bone disease. Positron emission tomography/computed tomography (PET/CT) combines functional and morphologic information to identify MM disease activity and assess treatment response. Magnetic resonance imaging (MRI) has excellent soft‐tissue contrast and is the modality of choice for bone marrow evaluation. This review focuses on the imaging modalities available for MM patient management, highlighting advantages, disadvantages, and applications of each.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.25846