Antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries: a randomised controlled trial

Objectives The aim of this study was to compare the antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries (S-ECC). Materials and methods The study was conducted in 92 children with S-ECC. Patients who completed dental treatment under...

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Bibliographic Details
Published in:Clinical oral investigations 2020-06, Vol.24 (6), p.2129-2136
Main Authors: Erkmen Almaz, Merve, Akbay Oba, Aylin
Format: Article
Language:English
Subjects:
Anesthesia
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Bacteria
Calcium phosphates
Cariostatic Agents - pharmacology
Casein
Child
Child, Preschool
Childhood
Children
Clinical trials
Dental caries
Dental Caries - drug therapy
Dental Caries - prevention & control
Dentistry
Fluorides
Fluorides, Topical - pharmacology
Humans
Medicine
Original Article
Patients
Saliva
Sodium Fluoride
Tricalcium phosphate
Xylitol
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Summary:Objectives The aim of this study was to compare the antibacterial activity of fluoride varnishes containing different agents in children with severe early childhood caries (S-ECC). Materials and methods The study was conducted in 92 children with S-ECC. Patients who completed dental treatment under general anaesthesia were included in the study. Patients were divided randomly into four groups: 5% sodium fluoride (SF) control group ( n  = 23), 5% SF with tricalcium phosphate (TCP) ( n  = 23), 5% SF with xylitol-coated calcium and phosphate (CXP) ( n  = 23) and 5% SF with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) ( n  = 23). Saliva mutans streptococci (MS) and lactobacilli (LB) levels were evaluated by taking saliva samples at baseline (T 0 ), 1 month (T 1 ) and 3 months (T 2 ) after treatment. Results All groups showed a significant decrease in MS and LB levels at T 1 ( P  
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-020-03300-w