Effect of bilateral salpingo-oophorectomy on the overall survival of premenopausal patients with stage I low-grade endometrial stromal sarcoma; a National Cancer Database analysis

Investigate the prevalence of bilateral salpingo-oophorectomy (BSO) for women ≤50 years with early stage low-grade endometrial stromal sarcoma (LGESS) and its impact on overall survival (OS). Women ≤50 years, diagnosed with stage I LGESS and managed with hysterectomy between 2004 and 2015 were ident...

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Bibliographic Details
Published in:Gynecologic oncology 2020-06, Vol.157 (3), p.634-638
Main Authors: Nasioudis, Dimitrios, Mastroyannis, Spyridon A., Latif, Nawar A., Ko, Emily M., Haggerty, Ashley F., Kim, Sarah H., Morgan, Mark A., Giuntoli, Robert L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Databases, Factual
Female
Humans
Middle Aged
Neoplasm Grading
Neoplasm Staging
Ovary
Retrospective Studies
Salpingo-oophorectomy - methods
Sarcoma
Sarcoma, Endometrial Stromal - mortality
Sarcoma, Endometrial Stromal - surgery
Survival Analysis
Uterus
Young Adult
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Summary:Investigate the prevalence of bilateral salpingo-oophorectomy (BSO) for women ≤50 years with early stage low-grade endometrial stromal sarcoma (LGESS) and its impact on overall survival (OS). Women ≤50 years, diagnosed with stage I LGESS and managed with hysterectomy between 2004 and 2015 were identified from the National Cancer Database. Patient demographics were recorded and compared with the chi-square test. OS for patients diagnosed between 2004 and 2014 with at least one month of follow-up was assessed using Kaplan-Meier curves, and compared with the log-rank test. A total 743 patients with a median age of 44 years met the inclusion criteria. Use of radiatiotherapy (9%), chemotherapy (0.8%) and hormonal therapy (11%) was infrequent. BSO was performed in 541 (72.8%) patients. Patients who had ovarian preservation (OP) were younger (median age 43 vs 45 years, p 
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2020.04.001