Indwelling catheterization, renal stones, and hydronephrosis are risk factors for symptomatic Staphylococcus aureus-related urinary tract infection

Purpose Staphylococcus aureus is a relatively uncommon causative agent of urinary tract infection (UTI). However, the clinical features of S. aureus -related UTI are unclear. Thus, we aimed to clarify how patients with S. aureus bacteriuria develop UTI and determine the features and clinical risk fa...

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Bibliographic Details
Published in:World journal of urology 2021-02, Vol.39 (2), p.511-516
Main Authors: Kitano, Hiroyuki, Shigemoto, Norifumi, Koba, Yumiko, Hara, Toshinori, Seiya, Kashiyama, Omori, Keitaro, Shigemura, Katsumi, Teishima, Jun, Fujisawa, Masato, Matsubara, Akio, Ohge, Hiroki
Format: Article
Language:English
Subjects:
Bacteriuria
Body mass index
Calculi
Catheterization
Diabetes mellitus
Drug resistance
Glomerular filtration rate
Hydronephrosis
Hyperplasia
Intubation
Kidneys
Medicine
Medicine & Public Health
Methicillin
Nephrolithiasis
Nephrology
Oncology
Original Article
Patients
Penicillin
Prostate
Risk factors
Staphylococcus aureus
Staphylococcus infections
Urinary tract
Urinary tract diseases
Urinary tract infections
Urogenital system
Urology
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Summary:Purpose Staphylococcus aureus is a relatively uncommon causative agent of urinary tract infection (UTI). However, the clinical features of S. aureus -related UTI are unclear. Thus, we aimed to clarify how patients with S. aureus bacteriuria develop UTI and determine the features and clinical risk factors of symptomatic S. aureus -related UTI. Methods We performed a retrospective study of patients at the Hiroshima University Hospital for whom S. aureus had been isolated from urine culture from January 2010 to December 2017. The characteristics (age, sex, body mass index, indwelling catheterization, renal stones, hydronephrosis, anticancer drug use, diabetes mellitus, steroid use, serum albumin, antibiotic use in the past 1 month, estimated glomerular filtration rate, benign prostate hyperplasia, and neurogenic bladder) of patients with UTI and those without UTI were compared, and the risk factors for S. aureus- related UTI were identified by multiple logistic regression model. Results A total of 286 patients with S. aureus bacteriuria were analyzed; 33 patients developed UTI. The causative pathogens were methicillin-sensitive S. aureus and methicillin-resistant S. aureus (MRSA) in 14 and 19 patients, respectively, who developed UTI. This study demonstrated that indwelling catheterization, hydronephrosis, and renal stones are significantly associated with S. aureus -related UTI ( p  = 0.01, odds ratio = 3.1; and p  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-020-03223-x