Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review

Purpose Acinic cell carcinoma (ACCs) is uncommon malignant epithelial neoplasm of the salivary glands; the most common presentation is a well-defined painless solid mass. Diagnosis of ACCs is frequently complicated, due to its similarity with benign tumors. Methods A review of the literature availab...

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Published in:European archives of oto-rhino-laryngology 2020-10, Vol.277 (10), p.2673-2679
Main Authors: Cavaliere, M., De Luca, P., Scarpa, A., Savignano, L., Cassandro, C., Cassandro, E., Iemma, M.
Format: Article
Language:English
Subjects:
Carcinoma
Carcinoma, Acinar Cell - diagnosis
Carcinoma, Acinar Cell - therapy
Head and Neck Surgery
Humans
Medicine
Medicine & Public Health
Neurosurgery
Otorhinolaryngology
Parotid Gland - diagnostic imaging
Parotid Neoplasms - diagnosis
Parotid Neoplasms - therapy
Radiotherapy, Adjuvant
Review Article
Salivary Glands
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Summary:Purpose Acinic cell carcinoma (ACCs) is uncommon malignant epithelial neoplasm of the salivary glands; the most common presentation is a well-defined painless solid mass. Diagnosis of ACCs is frequently complicated, due to its similarity with benign tumors. Methods A review of the literature available on ACCs was carried out. Studies were sourced from PubMed with searching of relevant headings and sub-headings and cross-referencing. Results There are no clear characteristics of ACCs found on CT, MRI and ultrasound imaging. The management of the ACC, a rare malignancy of the parotid gland, is often difficult and controversial. Radical surgery is the best treatment option. The role of radiotherapy remains controversial: the precise indications and oncologic effects of adjuvant radiotherapy in ACC of the parotid gland are not well known. There is insufficient literature regarding the chemotherapy for metastatic ACC. Conclusion Knowledge about ACC, a rare malignancy of parotid gland, has changed over the past few decades. More clinical randomized works would be needed, both to assess the real effectiveness of radio and chemotherapy and to have an unanimous consensus about their indications.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-020-05998-6