Recent Advances of pH‐Induced Charge‐Convertible Polymer‐Mediated Inorganic Nanoparticles for Biomedical Applications

The incorporation of functional polymers and inorganic nanoparticles into nanoplatforms has the potential to produce personalized nanomedicine systems for further biomedical applications. Polymers that endow inorganic nanoparticles with unique surface properties for prolonged blood circulation and i...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2020-11, Vol.41 (21), p.e2000106-n/a
Main Authors: Yang, Hong Yu, Li, Yi, Lee, Doo Sung
Format: Article
Language:English
Subjects:
Biomedical materials
Blood circulation
cellular uptake
charge‐convertible polymers
disease diagnosis
disease therapy
inorganic nanoparticles
Magnetic permeability
Nanoparticles
Nanotechnology
Permeability
pH effects
Polymers
Quantum dots
Surface properties
tumor targeting
Tumors
Upconversion
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Summary:The incorporation of functional polymers and inorganic nanoparticles into nanoplatforms has the potential to produce personalized nanomedicine systems for further biomedical applications. Polymers that endow inorganic nanoparticles with unique surface properties for prolonged blood circulation and improved tumor targeting and cellular uptake are especially desired. pH‐induced charge‐switchable polymers are sensitive to the pH of the tumor environment and maintain a negative or neutral charge in blood circulation, increasing their circulation time and enhancing tumor accumulation via the enhanced permeability and retention effect. This type of polymer further transforms its charge to positive in acidic tumor locations to promote cellular uptake. Furthermore, the combination of pH‐induced charge‐switchable polymers with various inorganic nanoparticles (e.g., magnetic nanoparticles, gold nanoparticles, quantum dots, and upconversion materials) activates their intrinsic functions in in situ diagnosis and disease therapy. This review briefly overviews the recent progress in the development and application of various pH‐induced charge‐convertible polymers functionalized with different types of inorganic nanoparticles for different biomedical applications. More importantly, future developments in this field are also discussed. This review discusses pH‐induced charge‐convertible polymer‐mediated inorganic nanoparticles and their applications in enhanced diagnosis and therapy of diseases, drug delivery, and as antibacterial agents.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.202000106