Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation

Although there is increased understanding of the alopecia areata (AA) pathogenesis based on studies in scalp tissues, little is known about its systemic profile. To evaluate the blood proteomic signature of AA and determine biomarkers associated with increased disease severity. In a cross-sectional...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2021-02, Vol.84 (2), p.370-380
Main Authors: Glickman, Jacob W., Dubin, Celina, Renert-Yuval, Yael, Dahabreh, Dante, Kimmel, Grace W., Auyeung, Kelsey, Estrada, Yeriel D., Singer, Giselle, Krueger, James G., Pavel, Ana B., Guttman-Yassky, Emma
Format: Article
Language:English
Subjects:
Alopecia areata
atherosclerosis
atopic dermatitis
biomarkers
blood
cardiovascular
inflammation
OLINK
proteomics
psoriasis
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Summary:Although there is increased understanding of the alopecia areata (AA) pathogenesis based on studies in scalp tissues, little is known about its systemic profile. To evaluate the blood proteomic signature of AA and determine biomarkers associated with increased disease severity. In a cross-sectional study, we assessed 350 inflammatory and cardiovascular proteins using OLINK high-throughput proteomics in patients with moderate to severe AA (n = 35), as compared with healthy individuals (n = 36), patients with moderate to severe psoriasis (n = 19), and those with atopic dermatitis (n = 49). Seventy-four proteins were significantly differentially expressed between AA and control individuals (false discovery rate,
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2020.04.138