Scaffold‐Free Bio‐3D Printing Using Spheroids as “Bio‐Inks” for Tissue (Re‐)Construction and Drug Response Tests

In recent years, scaffold‐free bio‐3D printing using cell aggregates (spheroids) as “bio‐inks” has attracted increasing attention as a method for 3D cell construction. Bio‐3D printing uses a technique called the Kenzan method, wherein spheroids are placed one‐by‐one in a microneedle array (the “Kenz...

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Bibliographic Details
Published in:Advanced healthcare materials 2020-08, Vol.9 (15), p.e1901831-n/a
Main Authors: Murata, Daiki, Arai, Kenichi, Nakayama, Koichi
Format: Article
Language:English
Subjects:
3-D printers
bio‐3D printers
bio‐ink
Ink
Inks
Pharmaceutical Preparations
Printers
Printing
Printing, Three-Dimensional
Scaffolds
scaffold‐free printing
Spheroids
Three dimensional printing
Tissue Engineering
tissue reconstruction
Tissue Scaffolds
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Summary:In recent years, scaffold‐free bio‐3D printing using cell aggregates (spheroids) as “bio‐inks” has attracted increasing attention as a method for 3D cell construction. Bio‐3D printing uses a technique called the Kenzan method, wherein spheroids are placed one‐by‐one in a microneedle array (the “Kenzan”) using a bio‐3D printer. The bio‐3D printer is a machine that was developed to perform bio‐3D printing automatically. Recently, it has been reported that cell constructs can be produced by a bio‐3D printer using spheroids composed of many types of cells and that this can contribute to tissue (re‐)construction. This progress report summarizes the production and effectiveness of various cell constructs prepared using bio‐3D printers. It also considers the future issues and prospects of various cell constructs obtained by using this method for further development of scaffold‐free 3D cell constructions. Scaffold‐free bio‐3D printing using spheroids as “bio‐inks” contributes to tissue (re‐)construction and drug response tests. Spheroids are placed one‐by‐one in a microneedle array (the “Kenzan”) using a bio‐3D printer. The production and effectiveness of various cell constructs prepared using the bio‐3D printer are summarized, and the future issues and prospects for further development of the constructs are considered.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201901831