Epidemiology of thrombosis in Canadian neonatal intensive care units

Objective To assess the rate, location, risk factors, management, and outcomes of neonatal thrombosis (NT). Design A retrospective study investigating infants admitted to NICUs in Canadian Neonatal Network between January 2014 and December 2016 and diagnosed with NT. Each infant with NT was matched...

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Bibliographic Details
Published in:Journal of perinatology 2020-07, Vol.40 (7), p.1083-1090
Main Authors: El-Naggar, Walid, Yoon, Eugene W., McMillan, Douglas, Afifi, Jehier, Mitra, Souvik, Singh, Balpreet, da Silva, Orlando, Lee, Shoo K., Shah, Prakesh S.
Format: Article
Language:English
Subjects:
692/308/174
692/700/1720
Anticoagulants (Medicine)
Arteries
Asphyxia neonatorum
Blood clot
Clinical trials
Epidemiology
Health aspects
Heparin
Hospitals
Infants
Infants (Premature)
Intensive care
Intensive care units
Low molecular weights
Management
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Molecular weight
Neonatal care
Neonatal intensive care
Neonates
Newborn babies
Pediatric Surgery
Pediatrics
Portal vein
Risk analysis
Risk factors
Risk management
Strategic planning (Business)
Thromboembolism
Thrombosis
Veins
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Summary:Objective To assess the rate, location, risk factors, management, and outcomes of neonatal thrombosis (NT). Design A retrospective study investigating infants admitted to NICUs in Canadian Neonatal Network between January 2014 and December 2016 and diagnosed with NT. Each infant with NT was matched with an infant without NT. Results Of 39,971 infants, 587 (1.5%) were diagnosed with NT: 440 (75%) venous, 112 (19%) arterial, 29 (5%) both. NT rate was 1.4% in full-term and 1.7% in preterm infants. Venous thrombi occurred most commonly in the portal vein and arterial thrombi in the cerebral artery. Conservative management and low molecular weight heparin were the most common treatment modalities. Hospital stay was longer ( p  
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-020-0678-1