Unwind and Relax: DDX3X RNA Helicase as a Critical Mediator of Cortical Neurogenesis

In this issue of Neuron, Lennox et al. (2020) report the largest cohort of patients to date with DDX3X syndrome, discovering unique genotype-phenotype relationships that inform molecular pathogenesis. They then uncover unique roles of DDX3X in cortical neuron development and ribonucleoprotein granul...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2020-05, Vol.106 (3), p.357-358
Main Authors: Vuocolo, Blake, Holder, J. Lloyd
Format: Article
Language:English
Subjects:
DNA helicase
Genotypes
Investigations
Metabolism
Microcephaly
Mutation
Neurogenesis
Neurons
Pathogenesis
Phenotypes
Proteins
RNA helicase
X chromosomes
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Summary:In this issue of Neuron, Lennox et al. (2020) report the largest cohort of patients to date with DDX3X syndrome, discovering unique genotype-phenotype relationships that inform molecular pathogenesis. They then uncover unique roles of DDX3X in cortical neuron development and ribonucleoprotein granule formation. In this issue of Neuron, Lennox et al. (2020) report the largest cohort of patients to date with DDX3X syndrome, discovering unique genotype-phenotype relationships that inform molecular pathogenesis. They then uncover unique roles of DDX3X in cortical neuron development and ribonucleoprotein granule formation.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2020.03.035